Publicaciones Centro de Estudios de las Proteínas

Publicaciones del CEP

(Si desea obtener copia de algún artículo, lo puede solicitar a la dirección electrónica que aparece al final de cada título)

2021

Alvarez C, Soto C, Cabezas S, Alvarado-Mesén J, Laborde R, Pazos F, Ros U, Hernández AM, Lanio ME. Panorama of the Intracellular Molecular Concert Orchestrated by Actinoporins, Pore-Forming Toxins from Sea Anemones. Toxins (Basel). 2021 Aug 13;13(8):567. doi: 10.3390/toxins13080567. PMID: 34437438 Free PMC article. Review. MDPI, Basel, Switzerland, Impact Factor: 4.546 (2020), Q1 (G1)
Carmen Soto Febles, Lena de León Esperón, Javier Alvarado-Mesén, Flavia Llorente Álvarez, Arianna Yglesias, Hermis Rodríguez, Rancés Blanco Santana, María E. Lanio, Isabel Fabiola Pazos Santos, Ana M. Hernández, Carlos Álvarez, Cell death mechanisms induced by pore forming toxins with special focus on actinoporins REVISTA CUBANA DE CIENCIAS BIOLÓGICAS ISSN: 2307-695X • VOL. 8 • N.o 2 • JULIO — DICIEMBRE • 2020 • pp. 1 – 22(G4)
Aisel Valle Garay, Isabel Fabiola Pazos Santos, Jose Antonio Pereiro-Morejón, H. González-Alvarez, Luis Benito Pérez-Socas, Liem Canet Santos, Camilo Ayra-Pardo, Yadira de la Patría Hervis Valdés. Rational approach of the structure-function relationship using chimeric isoforms provides new insights into the functional differences of sticholysins. RCCB, Vol. 8 • N.o 2 • julio — diciembre • 2020 • pp. 1 – 17(G4)
María del Carmen Luzardo. Homenaje a dos fundadores del Centro de Estudio de Proteínas (carta al editor) REVISTA CUBANA DE CIENCIAS BIOLÓGICAS RNPS: 2362 • ISSN: 2307-695X • VOL. 8 • N.o 2 • JULIO— DICIEMBRE • 2020 • pp. 1-3
María Victoria Iglesias Rodríguez1, Lirialis García Mesa, Eudalys Ortiz Guilarte, Carlos Manuel Álvarez Valcárcel, Gladys Margarita Lugioyo Gallardo, Roberto Rafael Núñez Moreira. Influencia del pH y la concentración de NaCl en el crecimiento y emisión de luz de dos cepas de Vibrio harveyi. Biotecnología Aplicada 2020, 37 (4) Scimago H index: 15, Cuartil Scimago: Q4 (Applied Microbiology and Biotechnology); SCImago Journal Rank (SJR): 0.20; Impact Score: 0.13 (mcluzardo@fbio.uh.cu)
Leina Moro-Pérez, Sum Lai Lozada-Chang, Gabriela Rivas-García, Carlos Álvarez, Laritza Rojas-Pérez, Tammy Boggiano-Ayo, Yamile González-González. Purification and Conformational Characterization of a Novel Interleukin-2 Mutein. The Protein Journal 2021. doi.org/10.1007/s10930-021-10025-6 Scimago H index: 52, Cuartil Scimago: 2 (Analytical Chemistry); SCImago Journal Rank (SJR): 0.72; Impact Score: 2.371 (2020) (calvarez@fbio.uh.cu)
Ania de la Nuez Veulens, Yoanna María Álvarez Ginarte, Rolando Eduardo Rodríguez Fernández, Fabrice Leclerc, Luis Alberto Montero Cabrera. Prediction of Molecular Interactions And Physicochemical Properties Relevant For Vasopressin V2 Receptor Antagonism. DOI: 10.21203/rs.3.rs-639693/v1 (ania.delanuez@fbio.uh.cu)
Marcello Mascini, Emre Dikici, Julio A. Perez-Erviti, Sapna K. Deo, Dario Compagnone, Sylvia Daunert. A new class of sensing elements for sensors: Clamp peptides for Zika virus, Biosensors and Bioelectronics, Volume 191, 2021, 113471, ISSN 0956-5663,https://doi.org/10.1016/j.bios.2021.113471.
Raber HF, Sejfijaj J, Kissmann AK, Wittgens A, Gonzalez-Garcia M, Alba A, Vázquez AA, Morales Vicente FE, Erviti JP, Kubiczek D, Otero-González A, Rodríguez A, Ständker L, Rosenau F. Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candidaauris, C. parapsilosis and C. albicans Biofilms. Pathogens. 2021 Apr 20;10(4):496. doi: 10.3390/pathogens10040496. PMID: 33924039; PMCID:PMC8072573. (aotero@fbio.uh.cu)
Valdés Tresanco M.E., Arrebola Y., Rivera L., Almeida F., Sánchez B., Charli J.L, and Pascual Alonso I. (2021) Bestatin is a non-competitive inhibitor of porcine M1 family glutamyl aminopeptidase: insights for selective inhibitor design. Indian Journal of Natural Products and Resources. Vol. 12(2), June 2021, pp. 173-180 (isel@fbio.uh.cu)
Isel Pascual Alonso, Gabriela García 1, Lisset Díaz 1, Yarini Arrebola 1, Laura Rivera Méndez 1, Fabiola Almeida García 1, Mae Chappé Pacheco 2, Belinda Sánchez 3, Jean-Louis Charli (2021). Effect of non-competitive inhibitors of aminopeptidase N on viability of human and murine tumor cells. Pure and Applied Chemistry. https://doi.org/10.1515/pac-2020-1010 (isel@fbio.uh.cu)
Samgina, T. Y., Tolpina, M. D., Surin, A. K., Kovalev, S. V., Bosch, R. A., Alonso, I. P., … & Lebedev, A. T. (2021). Manual mass spectrometry de novo sequencing of the anionic host defense peptides of Cuban Treefrog Osteopilus septentrionalis. Rapid Communications in Mass Spectrometry, e9061. (Grupo 1 Web of Sciences FI; 2.2, H: 132, SJR: 0.51, Q2 Analytical Chemistry) (isel@fbio.uh.cu)
Mey Ling Reytor Gonzalez, Maday Alonso del Rivero Antigua (2021). Reviewing the experimental and mathematical factors involved in tight binding inhibitors Ki values determination: The bi-functional protease inhibitor SmCI as a test model. Biochimie 181: 86-95. GRUPO I (maday@fbio.uh.cu)
Laritza Rojas, Aymara Cabrera-Munoz, Dayrom Gil Pradas, Jessica B. Gonzalez, Maday Alonso-del-Rivero, Yamile Gonzalez-Gonzalez (2021). Arginine substitution by alanine at the P1 position increases the selectivity of CmPI-II, a non-classical Kazal inhibitor. Biochemistry and Biophysics Reports 26: 101008. GRUPO I (maday@fbio.uh.cu)
Davier Gutierrez Gongora, Laritza Rojas Perez, Aymara Cabrera Muñoz, Maday Alonso
Del Rivero Antigua (2021). Biomedical and biological relevance of Subtilases from the S8 family, diverse and widely distributed Serine Peptidases. Revista Cubana de Ciencias Biológicas 9: 1-13. GRUPO II (maday@fbio.uh.cu)
Alberto del Monte-Martínez, Madelyn Sardiñas-Padrón, Mario Pupo-Meriño, Jorge González-Bacerio, José Manuel Guisán (2020) Aqueous two-phase systems for purification of penicillin acylase enzyme from Escherichia coli. Revista Cubana de Ciencias Biológicas. 8(2):1-13. RNPS: 2362 • ISSN: 2307-695X (adelmonte@fbio.uh.cu)
Pedro L. Arruebo‑Rivera, Freddy Castillo‑Alfonso, Amanda Troya, Yosberto Cárdenas‑Moreno, Patricia Pérez‑Ramos, Jorge González‑Bacerio, José M. Guisán Seijas, Alberto del Monte-Martínez (2021) Modeling and Experimental Validation of Algorithms for Maximum Quantity of Protein to be Immobilized on Solid Supports by Electrostatic Adsorption in the Strategy of Rational Design of Immobilized Derivatives. The Protein Journal. 40(4):576-588. IF: 1,317. SJR: 0,428. H: 50. Q3 (Biochemistry). https://doi.org/10.1007/s10930-021-09992-7 (adelmonte@fbio.uh.cu)
Freddy Castillo‑Alfonso, Marcia M. Rojas, Irina Salgado‑Bernal, María E. Carballo, Roberto Olivares‑Hernández, Jorge González‑Bacerio, José M. Guisán, Alberto del Monte‑Martínez (2021) Optimization of theoretical maximal quantity of cells to immobilize on solid supports in the rational design of immobilized derivatives strategy. World Journal of Microbiology and Biotechnology. 37(9): 2-11. IF: 2,477. SJR: 0,72. H: 83. Q2 (Applied Microbiology and Biotechnology). https://doi.org/10.1007/s11274-020-02972-6 (adelmonte@fbio.uh.cu)
Freddy Castillo Alfonso, Gabriel Vigueras-Ramírez, Luis Manuel Rosales-Colunga, Alberto del Monte-Martínez and Roberto Olivares Hernández (2021) Propionate as the preferred carbon source to produce 3-indoleacetic acid in B. subtilis: comparative flux analysis using five carbón Sources. Molecular Omics. https://doi.org/10.1039/d1mo00039j (adelmonte@fbio.uh.cu)
Bessy V. Cutiño-Avila, María I. Sánchez-López, Yosberto Cárdenas-Moreno, Michael González-Durruthy, Miguel Ramos-Leal, Gilda Guerra-Rivera, Jorge González-Bacerio, José M. Guisán, Juan M. Ruso, Alberto del Monte-Martínez (2021) Modeling and experimental validation of covalent immobilization of Trametes maxima laccase on glyoxyl and MANA-Sepharose CL 4B supports, for the use in bioconversion of residual colorants. Biotechnol Appl Biochem. 1-13. IF: 1,638. SJR: 0,42. H: 67. Q2 (Process Chemistry and Technology). https://doi.org/10.1002/bab.2125 (adelmonte@fbio.uh.cu)
Melaine González-García, Fidel Morales-Vicente, Erbio Díaz Pico, Hilda Garay, Daniel G. Rivera,Mark Grieshober, Lia Raluca Olari, Rüdiger Groß, Carina Conzelmann, Franziska Krüger, Fabian Zech,Caterina Prelli Bozzo, Janis A. Müller, Alexander Zelikin, Heinz Raber, Dennis Kubiczek,Frank Rosenau, Jan Münch, Steffen Stenger, Barbara Spellerberg, Octavio L. Franco, Armando A. Rodriguez Alfonso, Ludger Ständker and Anselmo J. Otero-Gonzalez (2021) Antimicrobial Activity of Cyclic-Monomeric and DimericDerivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains. Biomolecules, 11, 745. https://doi.org/10.3390/biom1105074. Q2, FI: 3.935, Grupo 1. (aotero@fbio.uh.cu)
Ernesto M. Martell, Melaine González, Ludger Standker, and Anselmo J. Otero-Gonzalez, (2021) Host Defense Peptides as immunomodulators: the other side of the coin. Peptides, 146, 170644, https://doi:101.1016/j.peptides2021.170644. Q2, FI: 2.843, Grupo 1. (aotero@fbio.uh.cu)
Armando A. Rodríguez, Anselmo Otero-González, Maretchia Ghattas and Ludger Ständker, (2021) Discovery, Optimization, and Clinical Application of Natural Antimicrobial Peptides. Biomedicines, 9, 1381. https://doi.org/10.3390/biomedicines9101381. Q1, FI: 6.081, Grupo 1. (aotero@fbio.uh.cu)
Laborde RJ, Ishimura ME, Abreu-Butin L, Nogueira CV, Grubaugh D, Cruz-Leal Y, Luzardo MC, Fernández A, Mesa C, Pazos F, Álvarez C, Alonso ME, Starnbach MN, Higgins DE, Fernández LE, Longo-Maugéri IM, Lanio ME. Sticholysins, pore-forming proteins from a marine anemone can induce maturation of dendritic cells through a TLR4 dependent-pathway. Mol Immunol. 2021 Mar;131:144-154. doi: 10.1016/j.molimm.2020.12.032. URL: https://www.elsevier.com/locate/molimm, Impact Factor: 4.407, ranking it 117 out of 297 in Biochemistry & Molecular Biology, H-index 128, Q2 ISSN: 0161-5890 (G1) (mlanio@fbio.uh.cu)
Del Valle A, Acosta-Rivero N, Laborde RJ, Cruz-Leal Y, Cabezas S, Luzardo MC, Alvarez C, Labrada M, Rodríguez A, Rodríguez GL, Raymond J, Nogueira CV, Grubaugh D, Fernández LE, Higgins D, Lanio ME. Sticholysin II shows similar immunostimulatory properties to LLO stimulating dendritic cells and MHC-I restricted T cell responses of heterologous antigen. Toxicon. 2021 Sep;200:38-47. doi: 10.1016/j.toxicon.2021.06.020. www.elsevier.com, Official Journal of The Brazilian Society of Toxinology, The International Society on Toxinology and The North American Society of Toxinology. Impact Factor: 3.033, ranking it 159 out of 275 in Pharmacology & Pharmacy, Q3 ISSN: 0041-0101 (G1) (mlanio@fbio.uh.cu)
Lanio ME, Laborde RJ, Cruz-Leal Y, Fernández LE, Sánchez-Ferrás O, del Valle A, Lopetegui-González I, Luzardo MC, Álvarez C, Mesa C. Sticholisina II encapsulada en liposomas potencia una respuesta de linfocitos T citotóxicos específica al antígeno. Anales de la Academia de Ciencias de Cuba (AACC), 2021, 11(1), ene-abr. ISSN 2304-0106 | RNPS 2308 (G3) (mlanio@fbio.uh.cu)
Hoff CC, Azevedo MF, Thurler AB, Maluf SEC, Melo PMS, Alonso del Rivero M, González-Bacerio J, Carmona AK, Budu A, Gazarini ML (2021). Overexpression of Plasmodium falciparum M1 aminopeptidase promotes an increase in intracellular proteolysis and modifies the asexual erythrocytic cycle development. Pathogens 10:1452. doi: 10.3390/pathogens10111452. IF: 3,492. SJR: 0,984. H: 38. Q2 (Infectious Diseases).
González-Bacerio J, Arocha I, Aguado ME, Méndez Y, Marsiccobetre S, Izquierdo M, Rivera DG, Figarella K, Uzcategui NL (2021). KBE009: A bestatin-like inhibitor of the Trypanosoma cruzi acidic M17 aminopeptidase with in vitro anti-trypanosomal activity. Life 11:1037. doi: 10.3390/life11101037. IF: 3,817. SJR: 0,973. H: 33. Q2 (Biochemistry, Genetics and Molecular Biology). (jogoba@fbio.uh.cu)
González-Bacerio J, Izquierdo M, Aguado ME, Varela AC, González-Matos M, Alonso del Rivero M (2021). Using microbial metalo-aminopeptidases as targets in human infectious diseases. Microb. Cell 8(10):239-246. IS: 3,95. SJR: 1,241. H: 24. Q1 (Applied Microbiology and Biotechnology). (jogoba@fbio.uh.cu)
Aguado ME, González-Matos M, Izquierdo M, Quintana J, Field MC, González-Bacerio J (2021). Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase. Protein Expr. Purif. 183:105877. doi: 10.1016/j.pep.2021.105877. IF: 1,513. SJR: 0,497. H: 84. Q3 (Biotechnology).(jogoba@fbio.uh.cu)

2020

Izquierdo M, Lin D, O’Neill S, Zoltner M, Webster L, Hope A, Gray DW, Field MC, González-Bacerio J (2020). Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using RapidFire mass spectrometry. SLAS Discovery. doi: 10.1177/2472555220923367. (WoS, Scopus, IF: 2.192. SJR: 0.93. H: 7). (Q1 Analytical Chemistry). (jogoba@fbio.uh.cu)
Fidel E. M. Vicente, Melaine G. González, Hilda E. Garay, Erbio D. Pico, Asiel M. Jimenez, Jose A. Campos-Delgado, Pablo E. Rosi, Daniel G. Rivera, Chinea, Rosemeire Prieto, Elena Moreno Castillo, Steffen Stenger, Barbara Spellerberg, Dennis Kubiczek, Nicholas Bodenberger, Steffen Dietz, Frank Rosenau, LudgerStandker, Marcio Weber Paixao and Anselmo J. Otero-González (2019) Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity. ACS Omega vol 4: 19081−19095. (WoS, Scopus, IF: 2.58. SJR: 0.77. H: 27). (Q1 Chemistry). (aotero@fbio.uh.cu)
Dennis Kubiczek, CarolinFlaig, Heinz Raber, Steffen Dietz, Ann-Kathrin Kissmann, Thomas Heerde, Nicholas Bodenberger, Andreas Wittgens, Melaine Gonzalez-Garcia, Fan Kang, Octavio L. Franco, LudgerStaendker, Anselmo J. Otero-Gonzalez, Paul Walther, Kay E. Gottschalk, Tanja Weil and Frank Rosenau (2020) A Cerberus-inspired Anti-Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging “Superbug” Yeast Candida auris. Macromolecular Bioscience, 20(4). Doi.org/10.1002/mabi.2202000005. (WoS, Scopus, IF: 3.42. SJR: 0.83. H: 99). (Q1 Material Chemistry). (aotero@fbio.uh.cu)
Dennis Kubiczek, Heinz Raber, Melaine Gonzalez-García, Fidel Morales-Vicente, LudgerStaendker, Anselmo J. Otero-Gonzalez and Frank Rosenau. Derivates of the antifungal peptide Cm-p5 inhibit development of Candida auris biofilms. Antibiotics (IF: 2.92), vol 9, 363-369. Doi:10.3390/ antibiotics 9070363. (WoS, Scopus, IF: 2.192. SJR: 1.17. H: 26). (Q1 Pharmacology, Toxicology and Pharmaceutics). (aotero@fbio.uh.cu)
Isel Pascual Alonso, Laura Rivera, Mario E. Valdés Tresanco, Lotfi Bounaadja, Yarini Arrebola, Marjorie Schmitt, Luis Alvarez Lajonchere, Jean-Louis Charli&Isabelle Florent (2020) Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline. Zeitschriftfür Naturforschung C, DOI: 10.1515/ZNC-2019-0169 (IF 1.0). (WoS, Scopus, IF: 1.238. SJR: 0.26. H:64). (Q3 Biochemistry, Genetics and Molecular Biology).
Isel Pascual Alonso, Roberto Alonso Bosch, Aymara Cabrera Muñoz, Wilmer H. Perera, Jean-Louis Charli. Methanolic extracts of paratoid gland secretions from Cuban Peltophryne toads contain inhibitory activities against peptidases with biomedical relevance. Biotecnol Apl. 2019; 36(2):2221-7. (WoS, Scopus, IF: 0.36. SJR: 0.12. H: 15). (Q4 AppliedMicrobiology and Biotechnology). (isel@fbio.uh.cu)
Rivera Méndez L., Arrebola Y., Valdés-Tresanco M.E., Díaz-Guevara L., Bergado G., Sánchez B., Charli J.L., Pascual Alonso, I.* (2020) Bestatin and bacitracin inhibit porcine kidney cortex dipeptidyl peptidase IV activity and reduce human melanoma MeWo cell viability. International Journal of Biological Macromolecules. 164: 2944–2952 https://doi.org/10.1016/j.ijbiomac.2020.08.157 (WoS, Scopus, IF: 5.16. SJR: 0.97. H: 114).(Q1 Medicine Miscellanius).(isel@fbio.uh.cu)
Alberto del Monte-Martínez, Jorge González-Bacerio, Carlos M. Varela, Fernando Vega-Villasante, Rogelio Lalana-Rueda, Héctor Nolasco, Joaquín Díaz, José M. Guisán (2019) Screening and Immobilization of Interfacial Esterases from Marine Invertebrates as Promising Biocatalyst Derivatives. Applied Biochemistry and Biotechnology. https://doi.org/10.1007/s12010-019-03036-8 . (WoS, Scopus, IF: 2.27. SJR: 0.56. H: 103). (Q2 Applied Microbiology and Biotechnology). (adelmonte@fbio.uh.cu)
Yosberto Cárdenas-Moreno, Luis Ariel Espinosa, Alberto del Monte-Martínez, Julio Cesar VieytoNuñez, Michael González-Durruti, María Isabel Sánchez López (2019) Theoretical study on binding interactions of laccase-enzyme from Ganoderma weberianum with multiples ligand-substrates with biotechnological importance. Computational Biology and Chemistry. CBAC_2018_707. (WoS, Scopus, IF: 1.85. SJR: 0.45. H: 58). (Q3 Biochemistry). (adelmonte@fbio.uh.cu)
González García, M; Rodríguez, A; Alba, A; Vázquez, A.A; Morales Vicente, F.E., Pérez-Erviti, J; Spellerberg, B; Stenger, S; Grieshober, M, Conzelmann; C., Münch, J; Raber, H; Kubiczek, D; Rosenau, F; Wiese, S; Ständker, L; Otero-González, A.J. (2020) New Antibacterial Peptides from the Freshwater Mollusk Pomaceapoeyana (Pilsbry, 1927). Biomolecules, 10: 1473;doi:10.3390/biom10111473. (WoS, Scopus, IF: 4.08. SJR: 1.61. H: 44). (Q1 Biochemistry). (aotero@fbio.uh.cu)
Rodríguez Mallón, A., Javier González, L., Encinosa Guzmán, P. E., Bechara, G. H., Sanches, G. S., Pousa, S., Cabrera G., Cabrales A., Garay H., Mejías R., Raúl López Álvarez J., Bello Soto Y., Almeida F.,…& Álvarez, J. R. L. (2020). Functional and mass spectrometric evaluation of an anti-tick antigen based on the P0 peptide conjugated to Bm86 protein. Pathogens, 9(6), 513. (WoS, Scopus, IF: 3.018. SJR: 1.22. H: 29). (Q1 Microbiology). (fabiola.almeida@fbio.uh.cu)
Ania de la Nuez Veulens, Rolando E. Rodriguez, Yoanna M. Álvarez, Luis A Montero. In silico strategy for detailing the binding modes of a novel family of peptides proven as ghrelin receptor agonists. Journal of Molecular Modeling, 26, 294 (2020) https://doi.org/10.1007/s00894-020-04553-8. (ania.delanuez@fbio.uh.cu)
Enrique Noa, Juliet M. Enriquez, Liuber Y. Machado, Nibaldo L. González, Teresita de Jesús Montero, Viviana Falcón, Anamarys Suarez, Madelin Blanco, Marielis Cabrera, Yenicet Infante, Lien Laguna, Nelson Acosta, Laura S. Rizo, et al., Isolation from Cuban COVID-19 Patients. American J Rare Dis Diagn Ther. 2020;3(1): 009-015.
Martiza Gónzalez-Bravo, Nelson Acosta-Rivero, Karla Pereira-Yañez, Mariuska Matos-Terrero, Yssel Mendoza-Marí, Ariana Gracía-Ojalvo, et al. Applying Quantitative Immunogold Labeling Distributions of Cellular Compartments in Immunoelectron Microscopy Images to the Study of EGFR Intracellular Signaling. Biomedical Journal of Scientific & Technical Research (2020), Volume 26, 3, pp 19959-19966. DOI: 10.26717/BJSTR.2020.25.004352.
Alonso, I. P., Méndez, L. R., Almeida, F., Tresanco, M. E. V., Sánchez, Y. A., Hernández-Zanuy, Luis Álvarez Lajonchere, Dagmara Díaz, Belinda Sánchez, Isabelle Florent, Marjorie Schmitt, Miguel Cisneros, Jean Louis Charli (2020). Marine organisms: a source of biomedically relevant metallo M1, M2 and M17 exopeptidase inhibitors. Revista Cubana de Ciencias Biológicas, 8(2):1-36. (isel@fbio.uh.cu)
Pascual Alonso I., Arrebola Sánchez Y., Almeida García F., Valdés-Tresanco M.E., Rivera Méndez L., Hernández Zanuy A., Chappé Pacheco M., Sánchez Ramírez B., Charli J.L. (2020) Marine and coastal organisms: a source of biomedically relevant dipeptidyl peptidase IV inhibitors. Revista Cubana de Ciencias Biológicas. 8(2):1-16. (isel@fbio.uh.cu)
Daymara Sánchez Castro, Lisandra González Inguanzo, Alberto del Monte-Martínez, Marcia M. Rojas Badía (2019) Factibilidad biológica del uso de cepas de Bacilli productoras de ácido 3 indolacético en el crecimiento in vitro del cultivo del arroz. Revista Cubana de Ciencias Biológicas. 7 (1):1- 10 (adelmonte@fbio.uh.cu)
González-Bacerio J, Méndez Y, Rivera DG, Alonso del Rivero M, Gazarini ML, Chávez MÁ, Carmona AK (2020). New inhibitors of microbial M1 metallo-aminopeptidases obtained by chemical synthesis. Anales de la Academia de Ciencias de Cuba. 10(3):e814. Indizada en Latindex. (jogoba@fbio.uh.cu)
Alvarez C, Lanio, ME. Notes on the Anniversary of Center for Proteins Studies: 20 years at the Service to Cuban Science — A tribute to Professor Maya Chávez. Revista Cubana de Ciencias Biológicas 2020 8(2): 1 – 4. (calvarez@fbio.uh.cu)
Iglesias Rodríguez, M.V., Umaña Castro, R., Garcia Mesa, L., Ortiz Guilarte, E., Núñez Moreira, R., Álvarez Valcárcel, C., Lugioyo Gallardo, G.M. (2020). Caracterización fenotípica y molecular, e influencia de medios de cultivo, en el crecimiento y emisión de luz de bacterias del litoral de La Habana, Cuba. Revista de Biología Tropical, 68(4) (calvarez@fbio.uh.cu)
María Cristina Pico Beltrán y María del Carmen Luzardo Lorenzo. Método de simulación en la clase práctica “Recombinación de segmentos génicos de inmunoglobulinas”. RCCB Vol 8, No 2: 1-6, 2020 (mcluzardo@fbio.uh.cu)
Aisel Valle Garay, Yadira de la Patría Hervis Valdés, Jose Antonio Pereiro-Morejón, H. González-Alvarez, Luis Benito Pérez-Socas, Liem Canet Santos, Camilo Ayra-Pardo, Isabel Fabiola Pazos Santos. Rational approach of the structure-function relationship using chimeric isoforms provides new insights into the functional differences of sticholysins. RCCB, RNPS: 2362 • ISSN: 2307-695X • VOL. 8 • N.o 2 • JULIO — DICIEMBRE • 2020 • pp. 1 – 17 (fpazos@fbio.uh.cu)

2019

Yarini Arrebola, Laura Rivera, Alejandro Pedroso, Rory McGuire b, Mario E. Valdes Tresanco a,c, Gretchen Bergado d, Jean-Louis Charli e, Belinda Sánchez d and Isel Pascual Alonso (2019) Bacitracin is a non-competitive inhibitor of porcine M1 family neutral and glutamyl aminopeptidases. Natural Product Research. Doi:10.1080/14786419.2019.1678611 (WoS, Scopus, FI: 1.99. SJR: 0.6. H: 42). (isel@fbio.uh.cu)
Jonathan E. Forman, Christopher M. Timperley, Pål Aas, Mohammad Abdollahi, Isel Pascual Alonso, Augustin Baulig, Renate Becker-Arnold, Veronica Borrett, Flerida A. Cariño, Christophe Curty, David Gonzalez, Zrinka Kovarik, Roberto Martínez-Álvarez, Robert Mikulak, Evandro de Souza Nogueria, Ponnadurai Ramasami, Syed K. Raza, Ahmed E. M. Saeed, Koji Takeuchi, Cheng Tang, Ferruccio Trifirò, Francois Mauritz van Straten, Farhat Waqar, Volodymyr Zaitsev, Mongia Saïd Zina, Katarína Grolmusová, Guy Valente, Marlene Payva, Siqing Sun, Amy Yang and Darcy van Eerten (2018) Innovative technologies for chemical security. Pure Appl. Chem. 2018; 90(10): 1527–1557 (FI 3.386) (isel@fbio.uh.cu)
Isel Pascual Alonso, Alejandro Pedroso, Yarini Manuel Arrebola, Mario Ernesto Valdés Tresanco, Laura Rivera Méndez y Sandra Fortun (2018) La Aminopeptidasa A de mamíferos: características bioquímicas, funciones fisiológicas y su implicación en procesos fisiopatológicos en humanos. Revista Cubana de Ciencias Biologicas. 6. (2):1-20. (isel@fbio.uh.cu)
Aymara Cabrera-Muñoz, Pedro A. Valiente, Laritza Rojas, Maday Alonso-del-Rivero Antigua, José R. Pires. NMR structure of CmPI-II, a non-classical Kazal protease inhibitor: Understanding its conformational dynamics and subtilisin A inhibition. https://doi.org/10.1016/j.jsb.2019.03.011. Journal of Structural Biology. Volume 206, Issue 3, 1 June 2019, Pages 280-294 (WoS, Scopus, FI: 3.754. SJR:5.25 H: 132). (maday@fbio.uh.cu)
Giovanni Covaleda-Cortés, Martha Hernández, Sebastián Alejandro Trejo, Manuel Mansur, Sergi Rodríguez-Calado, Javier García-Pardo, Julia Lorenzo, Josep Vendrell, María Ángeles Chávez, Maday Alonso-del-Rivero and Francesc Xavier Avilés. Characterization, Recombinant Production and Structure-Function Analysis of NvCI, A Picomolar Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita versicolor. Mar. Drugs 2019, 17, 511; doi:10.3390/md17090511. (WoS, Scopus, FI: 3.772. SJR:0.86 H: 84, Q2). (maday@fbio.uh.cu)
Laritza Rojas, Alexandre Budu, Sarah El Chamy Maluf, Pollyana S. Melo, Mayrim M. Gomes Smaul, Adriana K. Carmona, Marcos L. Gazarini, Maday Alonso del Rivero. Proteolysis assessment in isolated Plasmodium falciparum living cells at the asexual blood stages. (2019). Revista Cubana de Medicina Tropical 2019;71(2):e350. (Scopus, SJR:0.15 H: 16, Q4). (maday@fbio.uh.cu)
Melaine González-García, Ludger Ständker, Anselmo J. Otero-González (2019) Antimicrobial peptides and multiresistant respiratory infections (2019) Revista Cubana de Medicina Tropical, Vol 71(2) (aotero@fbio.uh.cu)
Cruz-Leal Y, Grubaugh D, Nogueira CV, Lopetegui-González I, Del Valle A, Escalona F, Laborde RJ, Alvarez C, Fernández LE, Starnbach MN, Higgins DE, Lanio ME. The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes. (2018) Front Immunol. 9:2473. doi: 10.3389/fimmu.2018.02473. eCollection 2018 IF= 5.511, G1 (mlanio@fbio.uh.cu)
María Eliana Lanio, María del Carmen Luzardo Lorenzo, Isabel Fabiola Pazos Santos, Mayra Tejuca Martínez, Rady Laborde Quintana, Yoelys Cruz-Leal, Aisel Valle Garay, Luis Enrique Fernández Molina, Carlos M. Álvarez Valcárcel. Liposomas: herramientas útiles en la biofísica y la biomedicina. Capítulo 8 del libro: Nano-micro biotecnologías: Aplicaciones biomédicas y biotecnológicas. Coordinadores: Prof. Dra. María de los A. Chávez Planes, Prof. Dr. Joaquín Díaz Brito, Prof. Dra. Olimpia Arias de Fuentes. Editorial UH 2019. ISBN: 978-959-7251-30-9. págs 407. Premio Editorial UH 2016. Pág 281-308. (mlanio@fbio.uh.cu)
Hervis YP, Valle A, Dunkel S, Klare JP, Canet L, Lanio ME, Alvarez C, Pazos IF, Steinhoff HJ. Architecture of the pore forming toxin sticholysin I in membranes, J Struct Biol. 2019 Oct 1;208(1):30-42. IF= 3.754, G1 (fpazos@fbio.uh.cu)
Escalona Rodríguez F.A., Cruz Leal Y., Rivero Hernandez A.L., Lopetegui González I., Manso Vargas Á., Alvarez Valcarcel C.M. y cols. (2019). Una disección a los Sistemas No-Virales de Liberación de Ácidos Nucleicos / A Dissection of the Non-viral nucleid acids Delivery Systems. Revista Cubana de Ciencia Biológicas 6(3) 1-16. (mlanio@fbio.uh.cu)
Mesa-Galloso, P.A. Valiente, R.F. Epand, M.E. Lanio, R.M. Epand, C. Alvarez, D.P. Tieleman, U. Ros. “Membrane remodeling by the lytic fragment of sticholysinII: implications for the toroidal pore model” Biophysical Journal 2019 Biophys J. 2019 Sep 20. pii: S0006-3495(19)30793-3. doi: 10.1016/j.bpj.2019.09.018. IF: 3.665; SJR: 2.02; Cuartil Q1; H: 246 (calvarez@fbio.uh.cu)
Carlos Manuel Álvarez Valcárcel, Isabel Fabiola Pazos Santos, María Eliana Lanio Ruiz. Bases estructurales de las membranas biológicas. Capítulo 2. Nano-micro-biotecnologías y sus aplicaciones, Ed María de los Ángeles Chávez Planes Joaquín Díaz Brito, Olimpia Arias de Fuentes Editorial UH, 2019. pp. 85-118. (calvarez@fbio.uh.cu)
Yanira Méndez, German De Armas, Idalia Pérez, Tamara Rojas, Mario E. Valdés-Tresanco, Maikel Izquierdo, Maday Alonso del Rivero, Pedro A. Valiente, Aldrin V. Vasco, William L. Scott, Bernhard Westermann, Jorge González-Bacerio and Daniel G. Rivera (2019). Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics. Eur. J. Med. Chem. 163:481-499. (WoS, Scopus, FI: 4,816. SJR: 1,266. H: 127, Q1). (jogoba@fbio.uh.cu)
Maikel Izquierdo, Mirtha Elisa Aguado, Martin Zoltner, Jorge González-Bacerio (2019). High-level expression in Escherichia coli, purification and kinetic characterization of LAPTc, a Trypanosoma cruzi, M17-aminopeptidase. The Protein Journal. https://doi.org/10.1007/s10930-019-09823-w (WoS, Scopus, FI: 1,133. SJR: 0,451. H: 45, Q3). (jogoba@fbio.uh.cu)
Gisele Regina Rodrigues, Carlos López-Abarrategui, Inés de la Serna Gómez, Simoni Campos Dias, Anselmo Otero-González, Octavio Franco (2019) Antimicrobial magnetic nanoparticles based-therapies for controlling infectious diseases. Int J Pharm. 2019 Jan 30;555:356-367. doi: 10.1016/j.ijpharm.2018.11.043. Epub 2018 Nov 16. Review. PMID: 30453018(WoS, Scopus, FI: 4.213. SJR: 1.14. H: 190, Q1). (aotero@fbio.uh.cu)
Silvia Miriam Pell del Río, María del Carmen Luzardo Lorenzo y Marta Rosa Muñoz Campos. La enseñanza de la asignatura Bioética en la carrera Bioquímica y Biología Molecular. Revista Cubana de Educación Superior 2018; 37(3) http://scielo.sld.cu/scielo.php?script=sci_issuetoc&pid=0257-431420180003&lng=es&nrm=iso G2 (mcluzardo@fbio.uh.cu)
Ana C. Varela, German De Armas, Yanira Méndez, Maikel Izquierdo, Maday Alonso del Rivero, Daniel G. Rivera, Jorge Gonzalez Bacerio (2019). Structure-activity relationship of the inhibition of M1-aminopeptidases from Escherichia coli (ePepN) and Plasmodium falciparum (PfA-M1) by bestatin-derived peptidomimetics. Revista Cubana de Ciencias Biológicas. 7(1):1-21. (jogoba@fbio.uh.cu)
Laritza Rojas, Aymara Cabrera-Muñoz, Maday Alonso-del-Rivero. Proteasas: enzimas claves en la fase de vida de Plasmodium falciparum. RCCB. VOL. 7 • N.o 2 • JULIO — DICIEMBRE • 2019 • pp. 1 — 11 (maday@fbio.uh.cu)
Felipe Adonis Escalona Rodríguez, Yoelys Cruz Leal, Ada Laura Rivero Hernandez, Isbel Lopetegui González, Ángel Manso Vargas, Carlos Manuel Alvarez Valcarcel, Belinda Sánchez Ramírez, Leandro Ramos Souza Barbosa, Rosangela Itri, Maria Eliana Lanio Una disección a los Sistemas No-Virales de Liberación de Ácidos Nucleicos. Revista Cubana de Ciencia Biológicas 6(3) 1-16. (2019) G3 (mlanio@fbio.uh.cu)
Maritza Gonzalez Bravo, Nelson Acosta Rivero, Sirenia González Pozos, Juan Kourí Flores, José Tapia Ramírez, Jorge Berlanga Acosta, Viviana Falcón Cama. Cutaneous wound healing and role of myofibroblasts. Panorama Cuba y Salud; 13 (Especial): 505-510. (2018) URL: revpanorama.sld.cu. G3 (Latindex)
Maritza Gonzalez Bravo, Nelson Acosta Rivero, Sirenia González Pozos, Juan Kourí Flores, Jorge Berlanga Acosta, Viviana Falcón Cama. Quantitative immunoelectron microscopy to the study of EGF therapeutic effect on diabetic foot ulcers. Panorama Cuba y Salud; 14(1): 99-106. (2019) URL:http://www.revpanorama.sld.cu/index.php/rpan/article/view/ G3?

2018

Carmen Soto, Gretchen Bergado, Rancés Blanco, Tania Griñán, Hermis Rodríguez, Uris Ros, Fabiola Pazos, María E. Lanio, Ana M. Hernández, Carlos Alvarez. Sticholysin II-mediated cytotoxicity involves the activation of regulated intracellular responses that anticipates cell Biochimie 148 (2018) 18-35. IF: 3.188; SJR: 1,45; Cuartil Q1; H: 116. (calvarez@fbio.uh.cu)
Alvarado-Mesén, J., Solano-Campos, F., Canet, L., Pedrera, L., Hervis, Y. P., Soto, C., Borbón, H., Lanio, M. E., Lomonte, B., Valle, A., Álvarez, C. (2018). Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens. Biochimie, In Press. doi.org/10.1016/j.biochi.2018.07.013. IF: 3.188; SJR: 1,45; Cuartil Q1; H: 116. (calvarez@fbio.uh.cu)
Gustavo P. B. Carretero, Eduardo F. Vicente, Eduardo M. Cilli, Carlos M. Alvarez, Håvard Jenssen, Shirley Schreier. Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic α-helix in membrane binding and pore activity of sticholysins I and II. PLoS One. 2018, 13(8):e0202981. doi: 10.1371/journal.pone.0202981. eCollection 2018. IF: 2.766; SJR: 1.16; Cuartil Q1; H: 241. (calvarez@fbio.uh.cu)
Lima de Oliveira A, Maffud Cilli E, Ros U, Crusca E Jr, Lanio ME, Alvarez C, Schreier S, Aguiar Pertinhez T, Spisni A. Insights on the structure-activity relationship of peptides derived from Sticholysin II. Biopolymers. 2018 doi: 10.1002/bip.23097. IF: 1.990; SJR: 0.86; Cuartil Q2 (Biochemistry); H: 111 (calvarez@fbio.uh.cu)
Yolaine Delgado Gómez, Rodolfo Umaña Castro, Stefany Solano González, María V. Iglesias Rodríguez, Eudalys Ortiz Guilarte, Carlos Álvarez Valcárcel, Gladys M. Lugioyo Gallardo Phenotypic Characterization and Molecular Identification of A Luminescent Marine Bacterium Isolated From The NW Shelf of Cuba Biotecnia, 19, Núm. 3; 3-10, 2017 (calvarez@fbio.uh.cu)
Uris Ros, Gustavo P. B. Carretero, Joana Paulino, Edson Crusca Jr, Fabiola Pazos, Eduardo M. Cilli, Maria E. Lanio, Shirley Schreier, Carlos Alvarez. Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins. S0300-9084(18)30284-0. doi: 10.1016/j.biochi.2018.10.005 IF: 3.188; SJR: 1,45; Cuartil Q1; H: 116. (calvarez@fbio.uh.cu)
Mey Ling Reytor Gonzalez, Maday Alonso-del-Rivero Antigua, Lizbeth Hedstrom Petr Kuzmic, Jose Ricardo Pires (2018) Sabellastarte magnifica Carboxypeptidase Inhibitor: The first Kunitz inhibitor simultaneously interacting with carboxypeptidases and serine proteases 150 (2018) 37e47 (FI 3.18) (maday@fbio.uh.cu)
Isel Pascual, Pedro A. Valiente, Gabriela García, Mario E Valdés-Tresanco, Yarini Arrebola, Lisset Díaz, Lotfi Bounaadja, Rosa María Uribe, Mae Chappe, Isabelle Florent, Jean-Louis Charli. Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN). Biochimie BIOCHI-D-17-00200R1-1 142 (2017) 216-225 (FI 3.18) (isel@fbio.uh.cu)
Jonathan E. Forman, Christopher M. Timperley, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Isel Pascual Alonso, Augustin Baulig, Veronica Borrett, Flerida A. Cariño, Christophe Curty, David González Berrutti, Zrinka Kovarik, Roberto Martínez-Álvarez, Robert Mikulak, Nicia Maria Fusaro Mourão, Ramasami Ponnadurai, Slawomir Neffe, Syed K. Raza, Valentin Rubaylo, Koji Takeuchi, Cheng Tang, Ferruccio Trifirò, Francois Mauritz van Straten, Paula S. Vanninen, Volodymyr Zaitsev, Farhat Waqar, Zina, Mongia Saïd, Marc-Michael Blum, Hugh Gregg, Wesam S. Alwan, Elena Fischer, Siqing Sun,28e Pei Yang (2018)Advice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide. TALANTA Journal https://doi.org/10.1016/j.talanta.2018.04.022 (FI 4.24) (isel@fbio.uh.cu)
Christopher M. Timperley, Jonathan E. Forman, Mohammad Abdollahi,Abdullah Saeed Al-Amri, Isel Pascual Alonso, Augustin Baulig, Veronica Borrett,Flerida A. Cariño, Christophe Curty, David Gonzalez, Zrinka Kovarik, Roberto Martínez-Álvarez, Robert Mikulak, Nicia Maria Fusaro Mourão, Ponnadurai Ramasami,Slawomir Neffe, Syed K. Raza, Valentin Rubaylo, Koji Takeuchi, Cheng Tang,Ferruccio Trifirò, Francois Mauritz van Straten, Paula S. Vanninen, Volodymyr Zaitsev,Farhat Waqar, Mongia Saïd Zina, Stian Holen and Hope A. Weinstein. (2018) Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on isotopically labelled chemicals and stereoisomers in relation to the Chemical Weapons Convention. Pure and Applied Chemistry. doi.org/10.1515/pac-2018-0803 (FI 3.386) (isel@fbio.uh.cu)
Alberto del Monte-Martínez, Bessy V. Cutiño-Avila, and Jorge González-Bacerio. (2018) Rational Design Strategy as a Novel Immobilization Methodology Applied to Lipases and Phospholipases. Methods in Molecular Biology, 1835: 243-283. (adelmonte@fbio.uh.cu)
Nolasco-Soria, F. Moyano-López, F. Vega-Villasante, Alberto del Monte-Martínez, D. Espinosa-Chaurand, E. Gisbert, and H. R. Nolasco-Alzaga (2018) Lipase and Phospholipase Activity Methods for Marine Organisms. Methods in Molecular Biology, 1835: 139-167. (adelmonte@fbio.uh.cu)
Aisel Valle, Luis Benito Pérez-Socas, Liem Canet, Yadira de la Patria Hervis, German de Armas-Guitart, Diogo Martins-de-Sa, Jônatas Cunha Barbosa Lima, Adolfo Carlos Barros Souza, João Alexandre Ribeiro Gonçalves Barbosa, Sonia Maria de Freitas & Isabel Fabiola Pazos (2018) Self-homodimerization of an actinoporin by disulfide bridging reveals implications for their structure and pore formation. Scientific Reports 8:6614 | DOI:10.1038/s41598-018-24688-2. IF 4.12 (fpazos@fbio.uh.cu)
Otero-Gonzalez AJ, Morales-Vicente F, Gonzalez-Garcia M, Garay-Perez H, Wessjohann L, Garcia-Rivera D, Grieshober M, Stenger S, Standker L (2018) Chemical derivatives of Cm-p5, a mollusc-derived peptide, enhanced its antifungal properties and improved, significantly, its antibacterial activity in vitro. Pharmaceutics and Drug Delivery Research, DOI: 10.4172/2325-9604-C1-026, ISSN: 2325-9604. IF:0.5 (aotero@fbio.uh.cu)
Hernádez-González J E, Salas-Sarduy E, Hernández-Ramírez L F, Pascual M J, Álvarez D E, Pabón A, Leite V B P, Pascutti P G, and Valiente P A (2018) Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures BBA General Subjects Vol 1862 (12): 2911-2923 (DOI: 10.1016/j.bbagen.2018.09.015) IF:3.67

2017

Sheila Cabezas a, Sylvia Ho b, Uris Rosa,c, María E. Lanio a, Carlos Alvarez a, F. Gisou van der Goot b, (2017) Damage of eukaryotic cells by the pore-forming toxin sticholysin II: consequences of the potassium efflux Biochimica et BiophysicaActa 1859 982–992 G1 web of science IF: 3.66 calvarez@fbio.uh.cu
Rady J. Laborde, Oraly Sanchez-Ferras, María C. Luzardo, Yoelys Cruz-Leal, Audry Fernández, Circe Mesa, Liliana Oliver, LiemCanet, Liane Abreu-Butin, Catarina V. Nogueira, Mayra Tejuca, Fabiola Pazos, Carlos Álvarez, María E. Alonso, Ieda M. Longo-Maugéri, Michael N. Starnbach, Darren E. Higgins, Luis E. Fernández and María E. Lanio (2017) Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune ResponseJ ImmunolMarch 3, 2017, G1 IF: 5.2 mlanio@fbio.uh.cu
Mesa-Galloso H¹, Delgado-Magnero KH^1,2, Cabezas S¹, López-Castilla A³, Hernández-González JE¹, Pedrera L¹, Alvarez C¹, Peter Tieleman D², García-Sáez AJ⁴, Lanio ME¹, Ros U^1,4, Valiente PA¹ (2017) Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity Protein Sci.2017 Mar; 26(3):550-565. doi: 10.1002/pro.3104. Epub 2017 Feb 23. G1 IF:2.523
Soto C¹, Del Valle A¹, Valiente PA¹, Ros U², Lanio ME¹, Hernández AM³, Alvarez C⁴. Differential binding and activity of the pore-forming toxin sticholysin II in model membranes containing diverse ceramide-derived lipids.Biochimie. 2017 Apr 7. pii: S0300-9084(17)30087- IF:3.113 calvarez@fbio.uh.cu
Emir Salas-Sarduy 1,2,†, Yasel Guerra 1,†,‡, Giovanni Covaleda Cortés 3, Francesc Xavier Avilés 2,3,* and María A. Chávez Planes 1,2,* (2017) Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays Marine drugs . IF: 3.503
Vivian Montero-Alejo;a* Gerardo Corzo; b Javier Porro-Suardíaz; a Zenia Pardo-Ruiz; a Erick Perera; c Leandro Rodríguez-Viera; d Gabriela Sanchez-Díaz; e f ErixWiliam Hernandez-Rodríguez; e, f, Carlos Alvarez; g, Steve Peigneur; h, Jan Tytgat; h, Rolando Perdomo-Morales (2017) Panusin represents a new family of b-defensin-like peptides in invertebratesIn Developmental and Comparative Immunology 67 pp310-321 IF: 3.218 calvarez@fbio.uh.cu
A del Monte-Martínez A, González-Bacerio J, Cutiño-Avila B, Rojas J, Chappé M, Salas-Sarduy E, Pascual I, Guisán JM (2017). Rational design and synthesis of affinity matrices based on proteases immobilized onto cellulose membranes. Prep. Biochem. Biotechnol. 47(8):745-753. IF: 1,361. SJR: 0,395. H: 21. adelmonte@fbio.uh.cu
Doens D, Valiente P A, Mfuh A M, Vo A X T ,Tristan A, Carreno L, Quijada M, Nguyen V T, Perry G, Larionov O V, Lleonart R, Fernandez P L (2017) Identification of inhibitors of CD36-Amyloid beta binding as potential agents for Alzheimer’s disease. ACS Chemical Neuroscience (DOI: 10.1021/acschemneuro.6b00386). IF= 4.348
Hernández González JE, Hernández Álvarez L, Pascutti P G, and Valiente P A (2017) Predicting the binding modes of a series of peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships. Proteins: Structure, Functions and Bioinformatics (DOI: 10.1002/prot.25322). IF= 2.499
Covaleda, Giovanni Trejo, Sebastian A., Salas-Sarduy, Emir, del Rivero, Maday Alonso, Chavez, Maria Angeles, Aviles, Francesc X. (2017) ^a,^⁎NTENSITY FADING MALDI-TOF MASS SPECTROMETRY AND FUNCTIONAL PROTEOMICS ASSIGNMENTS TO IDENTIFY PROTEASE INHIBITORS IN MARINE INVERTEBRATES Journal of Proteomics Volume 165, 8 August 2017, Pages 75-92 IF:3.914 maday@fbio.uh.cu
Ahumada, M., Calderon, C., Lissi, E., Alvarez, C., Lanio, M.E., Pazos, F. The pore forming capacity of Sticholysin I in dipalmitoyl phosphatidyl vesicles is tuned by osmotic stress (2017) Chemistry and Physics of Lipids, 203, pp. 87-93. IF:3.361 fpazos@fbio.uh.cu
González-Bacerio J, Maluf SEC, Méndez Y, Pascual I, Florent I, Melo PMS, Budu A, Ferreira JC, Moreno E, Carmona AK, Rivera DG, Alonso del Rivero M, Gazarini ML (2017). KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library. Bioorg. Med. Chem. DOI: 10.1016/j.bmc.2017.06.047. IF: 2,93. jogoba@fbio.uh.cu
Isel Pascual Alonso, Lotfi Bounaadja, Laura Sánchez, Laura Rivera, Céline Tarnus, Marjorie Schmitt, Gabriela Garcia, Lisset Diaz, Aida Hernandez-Zanuy, Isabelle Florent. (2017) Aqueous extracts of marine invertebrates from Cuba coastline display neutral aminopeptidase inhibitory activities and effects on cancer cells and Plasmodium falciparum parasites. Indian Journal of Natural Products and Resources. 8 (2): 107-119. isel@fbio.uh.cu
Isel Pascual*, Pedro A. Valiente, Gabriela García, Mario E Valdés-Tresanco, Yarini Arrebola, Lisset Díaz, Lotfi Bounaadja, Rosa María Uribe, Mae Chappe, Isabelle Florent, Jean-Louis Charli. Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN). Biochimie BIOCHI-D-17-00200R1-1 DOI information: 10.1016/j.biochi.2017.09.015IF:3.113 Biochimie 142C (2017) pp. 216-225 isel@fbio.uh.cu
Otero-Gonzalez AJ, Lopez-Abarrategui C, Garay H, Franco OL, Campos-Dias S, Starnbach M, Wessjohann L and Reguera E (2017) Cm-p5: an antifungal mollusc-derived peptide conjugated with citric acid-modified manganese-ferrite nanoparticles with enhanced activity against Candida albicans in vitro. Journal of Pharmaceutics and Drug Delivery Research. Vol 6 (3, suppl), pag. 79. IF:0.5 aotero@fbio.uh.cu
González García M., Valdés M., Freitas C., Alba A., López C., San Juan J., Campos S., Luiz Franco O., Otero A. Actividad biológica complementaria in vitro del péptido antifúngico Cm-p5 y predicción in silico de sus regiones funcionales. Revista Cubana de Medicina Tropical. 2017; 69(1) 1-15. aotero@fbio.uh.cu
Valdés-Tresanco M E, Valdés-Tresanco M S, Valiente P A, Cocho G, Mansilla R, Nieto-Villar J M (2017) Protein surface roughness accounts for binding free energy of Plasmepsin II‐ligand complexes. J MolRecognit. (DOI: 10.1002/jmr.2661). IF:2.175
Alvarez C, Ros U, Valle A, Pedrera L, Soto C, Hervis P Y, Cabezas S, Valiente P A, Pazos F, Lanio M E (2017) Biophysical and Biochemical Strategies to Understand Membrane Binding and Pore formation by Sticholysins, Pore-Forming Proteins from a Sea Anemone. Biophysical Reviews (DOI: 10.1007/s12551-017-0316-0). IF:0.735 calvarez@fbio.uh.cu
Haydee Mesa Galloso, Karelia H. Delgado-Magnero, Uris Ros, Pedro A. Valiente, D. Peter Tieleman (2017) Dimerization, a Key Step for Pore Formation of Fragaceatoxin C, an Actinoporin from the Sea Anemone Actinia Fragacea, Biophisycal Journal Volume 112, Issue 3, Supplement 1, p524a–525a IF: 3.656
Viviana Falcon, Nelson Acosta-Rivero, Sirenia Gonzalez, Santiago Duenas-Carrera, Gillian Martinez-Donato, Ivon Menendez, Rocio Garateix, Jose A. Silva, Emilio Acosta, Juan Kourı. Ultrastructural and biochemical basis for hepatitis C virus morphogenesis. Virus Genes (2017) 53:151–164. DOI 10.1007/s11262-017-1426. IF:1,431
Viviana Falcón, Nelson Acosta-Rivero, Sirenia González, Santiago Dueñas-Carrera, Emilio Acosta Medina and Juan Kourı. Evidences of ultrastructural remodeling of ER-derived membranes and hepatitis C virus morphogenesis in human liver samples. Revista Cubana Medicina Tropical. Vol 68, N0 3, 2016.
Viviana Falcón, Nelson Acosta-Rivero,Sirenia González, Emilio Acosta Medina, Rocio Garateix Suarez, Jose Ángel Silva, Liz Alvarez-Lajonchere, Gillian Martínez-Donato. Santiago Dueñas. Clustered distribution of virus infected cells in the liver of patients with chronic hepatitis C. Revista Cubana Medicina Tropical. Vol 69, N0 1, 2017.
Falcón-Cama V, Fernández-Mayola M, Mendoza-Mari Y, Acosta-Rivero N, García-Ojalvo A, Bringas-Pérez R, Menéndez-Valdés I, Matos-Terrero M, López-Noudo L, et al. Epidermal Growth Factor based Therapy Promotes Intracellular Trafficking and Accumulation of its Receptor in the Nucleus of Fibroblasts from Diabetic Foot Ulcers. J Diabetic Complications Med (2016) 1, 3: 111.
Guisado-Bourzac, F, Romero del Sol, DL, Guisán Seijas JM, González-Bacerio J, Díaz J, Martins Soares A, del Monte-Martínez A (2017). A two-step purification procedure of phospholipases A2 from the sea anemone Condylactisgigantea. Rev. Cubana Quím. 29(1):133-149. Indizada en SciELO. IF: 0,016 adelmonte@fbio.uh.cu
Gabriela Rudd Garcés, María del Carmen Luzardo Lorenzo y Yamila Carpio.González. lnteracción entre el piojo de mar Lepeophtheirus salmonis y sus hospederos: desarrollo de vacunas contra este ectoparásito. Revista Cubana de Ciencias Biológicas, 2017, 5 ( 2): 1-13. mcluzardo@fbio.uh.cu

2016

Carlos Lopez-Abarrategui, Viviana Figueroa-Espi, Maria B. Lugo-Álvarez, Caroline D. Pereira, Hilda Garay, Joao A.R.G. Barbosa, Rosana Falcão, Linnavel Jiménez-Hernández, Osvaldo Estévez-Hernández, Edilso Reguera-Ruiz, Octavio L. Franco, Simoni Campos Dias and Anselmo J. Otero-Gonzalez (2016) The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5. International Journal of Nanomedicine, 11: 3849-3857 (WoS, Scopus, FI: 4.32; H: 64; SJR: 1.35). aotero@fbio.uh.cu
Ludovico Migliolo, Mário R. Felício, Marlon H. Cardoso, Osmar N. Silva, Mary-Ann E. Xavierd, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi Roca-Subira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J. Otero-Gonzalez, SóniaGonçalves, Nuno C. Santos, Octavio L. Franco (2016) Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2. Biochimica et Biophysica Acta (BBA)–Biomembranes. 1858 (7), Part A: 1488–1498 (WoS, Scopus, FI: 4.64; H: 138; SJR: 1.77). aotero@fbio.uh.cu
Yoelys Cruz-Leal, Alejandro López-Requena, IsbelLopetegui-González, Yoan J. Machado Hernández, Carlos Álvarez, Rolando Pérez Rodríguez, María E. Lanio. (2016) Phosphocholine-Specific Antibodies Improve T-Dependent Antibody Responses against OVA Encapsulated into Phosphatidylcholine-Containing Liposomes. Frontiers in Immunology, 7:1-13. (WoS, FI: 5.69, H: 14, SJR: 1,794) mlanio@fbio.uh.cu
Aymara Cabrera-Muñoz, Laritza Rojas, Maday Alonso-del-Rivero Antigua, José Ricardo Pires (2016). 1-¹H, ¹³C and ¹⁵N resonance assignments and secondary structure analysis of CmPI-II, a serine protease inhibitor isolated from marine snail Cenchritis muricatus. (2016) Biomol NMR Assign 10:1, 153-156 (WoS, FI: 0.687, H: 8, SJR: 0,393) maday@fbio.uh.cu
Aymara Cabrera-Muñoz; Laritza Rojas; Dayrom F Gil; Yamile González-González; Manuel Mansur; AyameyCamejo; Jose Ricardo Pires, Maday Alonso-del-Rivero (2016) Heterologous expression of Cenchritis muricatus protease inhibitor II (CmPI-II) in Pichia pastoris system: purification, isotopic labeling and preliminary characterization. Protein Expression and Purification 126: 127-136. (Scopus, FI: 1.407, H: 62, SJR: 0,721) maday@fbio.uh.cu
Lídice González, Rafael Sánchez, Laritza Rojas, Isel Pascual, Rossana García Fernández, María de los Á. Chávez Planes, Christian Betzel. (2016) Screening of protease inhibitory activity in twenty aqueous extracts of Cuban marine invertebrates. American Journal of Analytical Chemistry, 7, 319-331. (WoS, FI: 1.25, H: 19, SJR: 0,33)
García-Fernández, P. Ziegelmüller, L. González, M. Mansur, R. E. Sánchez, Y. Machado, U. Hahn, M. Á. Chávez. (2016) Expression in Pichia pastoris, purification and characterization of K13L (P1) and Y15S (P2´) mutants of ShPI-1, a protease inhibitor from Stichodactyla helianthus. Prot. Exp. Purif. 123 42-50. (Scopus, FI: 1.407, H: 62, SJR: 0,721)
Wilmer H. Perera Córdova, Suzana Guimarães Leitão, Geraldino Cunha-Filho, Roberto Alonso Bosch, Isel Pascual Alonso, Rogelio Pereda-Miranda, Rodrigo Gervou, Natália AraújoTouza, Luis Eduardo M. Quintas, François Noël. (2016) Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): inhibition of human kidney Na+/K+-ATPase activity. Toxicon 110, 27-34. (WoS, FI: 2,309, H: 88, SJR: 1,008) isel@fbio.uh.cu
Alberto del Monte-Martínez, Jorge González-Bacerio, Bessy Cutiño-Avila, Ritsie Ruiz, Rizette Avila, Miguel Ramos-Leal, Héctor Nolasco, Joaquín Díaz, José M. Guisán (2015). Esters biotransformation by immobilized interfacial esterases from the Caribbean Sea anemone Stichodactyla helianthus. Biotecnología Aplicada. 32:3201-3210. (Scopus, FI: no tiene, H: 8, SJR:0,123) adelmonte@fbio.uh.cu
Rossana García-Fernández, Steve Peigneur, Tirso Pons, Carlos Alvarez, Lídice González, María A. Chávez, and JanTytgat (2016). The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels. Toxins, 8,110. (WoS, FI: 3.571. H: 17, SJR: 1,033).
Valle, Y.P. Hervis, L.B.P. Socas, L. Canet, M. Faheem, J.A.R.G. Barbosa, M.E. Lanio, I.F. Pazos (2016). The multigene families of actinoporins (part II): Strategies for heterologous production in Escherichia coli. Toxicon. 118: 64-81.(WoS, FI: 2.429. H: 88, SJR: 1,008). fpazos@fbio.uh.cu
Miranda W, Van A N, Valiente PA, Noskov S. (2016) Improved QM/MM Linear Interaction Energy Model for Substrate Recognition in Zinc-Containing Metalloenzymes. Journal of Physical Chemistry B120(32)7824-35. (WoS, FI: 3.187. H: 314, SJR: 1,414)
Guerra Y, Valiente PA, Pons T, Berry C, Rudiño-Piñera R (2016) Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: could the aspartic protease inhibition has evolved from a canonical serine protease-binding loop?Journal of StructuralBiology, 195(2)259-71. (Scopus, FI: 2.570. H: 104, SJR: 2,637)
Montero-Alejo V, Corzo G, Porro-Suardíaz J, Pardo-Ruiz Z, Perera E, Rodríguez-Viera L, Sánchez-Díaz G, Hernández-Rodríguez EW, Álvarez C, Peigneur S, Tytgat J, Perdomo-Morales R. (2016) Panusin represents a new family of β-defensin-like peptides in invertebrates. Dev Comp Immunol. doi: 10.1016/j.dci.2016.09.002(Scopus, FI: 3.620. H: 1,335, SJR: 71) calvarez@fbio.uh.cu
Frenkel Guisado-Bourzac, Dolores Lázara Romero Del Sol, José Manuel GuisánSeijas, Jorge González-Bacerio, Joaquín Díaz Brito y Alberto del Monte-Martínez. (2016). Obtaining an affinity support for Phospholipase A₂ isolation and purification. Revista Cubana de Química, 28(2)595-609. (Scielo) adelmonte@fbio.uh.cu
Yordanis Pérez-Llano, María del Carmen Luzardo Lorenzo. (2016) Nuevo diseño para una clase práctica de visualización y análisis de la estructura tridimensional de las proteínas. Revista Cubana de Ciencias Biológicas. 5(1)65-70. (Scielo) mcluzardo@fbio.uh.cu
Álvarez C y Espinosa G (2016). Transformando la enseñanza experimental de la Bioquímica y la Biología Molecular en la Universidad de La Habana. Breve reflexión y propuestas a propósito del Plan de Estudios E. Revista Cubana de Ciencias Biológicas. 5(1)10-14. (Scielo) calvarez@fbio.uh.cu
García-Fernández, P. A. Valiente-Flores, C. Alvarez-Valcárcel (2016) Advanced School on Experimental and Bioinformatics Tools for Protein 3D Structure Determination and Analysis. Varadero, Cuba, November, 2015. Crystallographic Meeting Report. IUCr Newsletter 24(1). http://www.iucr.org/news/newsletter calvarez@fbio.uh.cu
Lanio M.E., Seeger M., Pazos I.F. (2016) Integración del programa de doctorado en Ciencias Biológicas a la Red Iberoamericana de Biotecnología Isla Negra (RIABIN). Revista Cubana de Ciencias Biológicas. 5(1)135-140. (Scielo) fpazos@fbio.uh.cu
Rojas L., Álvarez M., Francisco Morier L.F., Valdés O., Del Barrio G. (2016) Evaluación preliminar de la actividad antiviral del extracto de Laurencia obtusa frente a herpesvirus y virus dengue. Revista Cubana de Farmacia, 50(1). (Scielo) laritza@fbio.uh.cu
Yoelys Cruz Leal, María E. Lanio, et al. (2015) Contribución de las células B-1 a la respuesta de anticuerpos antígeno-especifica y a la polarización del fenotipo de macrófagos peritoneales inducidos por liposomas constituidos por fosfatidil colina. Anales de la Academia de Ciencias de Cuba. Vol. 5, No.3. (Latindex) mlanio@fbio.uh.cu
Castañeda-Guillot, C. and del Monte-Martínez A. (2015) Prebióticos y sus beneficios en la alimentación. Revista Gastrohnup. 17(3): 18-25. (LILACS, EBSCO) adelmonte@fbio.uh.cu

2015

García M de L, Borrero R, Lanio ME, Tirado Y, Alvarez N, Puig A, Aguilar A,Canet L, Mata Espinoza D, Barrios Payán J, Sarmiento ME, Hernández-Pando R, Norazmi MN, Acosta A. 2015. Protective effect of a lipid-based preparation from Mycobacterium smegmatis in a murine model of progressive pulmonary tuberculosis. Biomed Res Int. 2014;2014:273129. doi: 10.1155/2014/273129. Epub 2015 Dec 7.PubMed PMID: 25548767; PubMed Central PMCID: PMC4274834.(lcanet@fbio.uh.cu)
López-Abarrategui C., McBeth C., Mandal S.M., Zhenyu J. Sun., Heffron G.,Alba- Menéndez A., Migliolo L., Reyes-Acosta O., García-Villarino M., Nolasco D., Falcão R. , Cherobim M.D. , Dias S.C., Brandt W., Wessjohann L., Starnbach M., Franco O.L. and Otero-González A.J.2015. Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae). Aceptada en FASEB Journal (Web of Sci; IP: 5.48;SJR: 3.12; H: 212) FASEB Journal, 29(8): 3315-25. (aotero@fbio.uh.cu)
Rossana García-Fernández, Markus Perbandt, Dirk Rehders , Yamile González-González, Patrick Ziegemuller , Nicolas Pigoneau, Maria Chavez, Ulrich Hahn, Christian Betzel , Lars Redecke. 2015. Insights into the first 3D-structure of a BPTI Kunitz Type inhibitor -1 in complex with pancreatric elastase JBC VOL. 290, NO. 22, pp. 14154 –14165. (Rossana@fbio.uh.cu)
Valle, A.; Alvarado-Mesén, J.; Lanio, M. E. ; Álvarez, C.; Barbosa, J.A.R.G. ; Pazos, I.F. 2015. The multigene families of actinoporins (Part I): Isoforms and genetic structure. TOXICON, aceptado Toxicon. Sep 1;103:176-87 (aiselvalle@fbio.uh.cu)
Fidel E Morales, Hilda E Garay, Daniela F Muñoz, Yarelys E Augusto, Anselmo J Otero-González, Osvaldo Reyes Acosta, Daniel G Rivera. 2015. Aminocatalysis-Mediated on-Resin Ugi Reactions: Application in the Solid-Phase Synthesis of N-Substituted and Tetrazolo Lipopeptides and Peptidosteroids. Organic Letters 05/2015; DOI:10.1021/acs.orglett.5b01147. (aotero@fbio.uh.cu)
Viana, Juliane; Souza, Jessica; Freitas, Camila; Paul, Arghya; Alcaraz, Jarib; Lacorte, Cristiano; Migliolo, Ludovico; Andrade, Cesar A. S; Falcao, Rosana; Santos, Nuno; Goncalves, Sonia; Otero-Gonzalez, Anselmo; Khademhosseini, Ali; Dias, Simoni; L. Franco, Octavio. 2015. Antifungal nanofibers made by controlled release of sea animal derived peptide. Nanoscale 03/2015; 7(14). DOI:10.1039/C5NR00767D. (aotero@fbio.uh.cu)
Ros U and Garcia-Saez AJ. More than a pore: the interplay of pore forming proteins and lipid membrane. 2015. Journal of Membrane Biology 06/2015; DOI:10.1007/s00232-015-9820-y
Yamunadevi Subburaj, Uris Ros, Eduard Hermann, Rudi Tong , and Ana J. García-Saez. 2015. Toxicity of an -Pore-forming Toxin Depends on the Assembly Mechanism on the Target Membrane as Revealed by Single Molecule Imaging (2015) THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 8, pp. 4856–4865,
Hernández González JE, García-Fernández R, Valiente P A. 2015. Polar Desolvation and Position 226 of Pancreatic and Neutrophil Elastases Are Crucial to Their Affinity for the Kunitz-Type Inhibitors ShPI-1 and ShPI-1/K13L. Plos One (valiente@fbio.uh.cu)
Miranda W, Noskov S, and Valiente PA. 2015. Improving the LIE method for binding free energy calculations of protein-ligand complexes. Journal of Chemical Information and Modeling (DOI: 10.1021/acs.jcim.5b00012). (valiente@fbio.uh.cu)
Hernández Alvarez L, Naranjo Feliciano D, Hernández González JE, Soares RO, Barreto Gomes DE, Pascutti PG. 2015. Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches. PLoS Negl Trop Dis. 9(5):e0003759. (DOI: 10.1371/journal.pntd.0003759). (valiente@fbio.uh.cu)
Ros U, Rodríguez-Vera W, Pedrera L, Valiente PA, Cabezas S1, Lanio ME1, García-Sáez AJ2, Alvarez C3.. 2015. “Differences in activity of actinoporins are related with the hydrophobicity of their N-terminus.” Biochimie 116: 70-78. (calvarez@fbio.uh.cu)
Reytor ML, Reverter D, Trejo S, de Los Ángeles Chávez M, Avilés FX, Del Rivero MA 2015. Crystal structure of a tri domain BPTI Kunitz inhibitor in complex with human carboxypeptidase A4 revealed a novel and non canonical inhibition mechanism. J Biomol Struct Dyn. May;33 Suppl 1:136-7. doi: 10.1080/07391102.2015.1032840. (maday@fbio.uh.cu)
Ahumada, M., C. Calderon, Alvarez C, Lanio ME, Lissi EA. 2015. “Response of unilamellar DPPC and DPPC:SM vesicles to hypo and hyper osmotic shocks: A comparison.” Chem Phys Lipids 188: 54-60. (calvarez@fbio.uh.cu)
Pedrera L, Gomide AB, Sánchez RE, Ros U, Wilke N4, Pazos F1, Lanio ME1, Itri R2, Fanani ML, Alvarez C. 2015. “The Presence of Sterols Favors Sticholysin I-Membrane Association and Pore Formation Regardless of Their Ability to Form Laterally Segregated Domains.” Langmuir. Sep 2 (calvarez@fbio.uh.cu)
Mena Valdés Licet, Tamargo Santos Beatriz, Salas Olivet Eva, Plaza Paredes Luis Enrique, Blanco Hernández Yisel, Otero González Anselmo et al . 2015. Determinación de saponinas y otros metabolitos secundarios en extractos acuosos de Sapindus saponaria L. (jaboncillo). Rev Cubana Plant Med [revista en la Internet]. Mar [citado 2015 Sep 07]; 20(1): 106-116. (aotero@fbio.uh.cu)
Isel Pascual, Gabriela García, Laura Sánchez, Lisset Díaz, Llilian Arzola, Nelson Labrada, Yarini Arrebola, William Ernesto Miranda, María de los Angeles Chávez, Pedro Valiente y Jean-Louis Charli. 2015. La Aminopeptidasa N de mamíferos: características bioquímicas, funciones fisiológicas y su implicación en procesos fisiopatológicos en humanos / Aminopeptidase N from mammals: biochemical caracteristics, physiological functions and implication in physiopathological processes in humans… RCCB 4.1 Pp: 2-16. (isel@fbio.uh.cu)
Carlos López-Abarrategui, Anselmo J. Otero-González, Annia Alba-Menéndez, Edilso Reguera-Ruiz, and Octavio Luiz Franco. 2015. Nanoparticles as a Promise for Host Defense Peptide Therapeutics. In “Biological and Pharmaceutical Applications of Nanomaterials” (Polina Prokopovich Ed). CRC Press, Taylor and Francis Group, London, Chapter 5, Pags 129-148. ISBN 9781482250169. (aotero@fbio.uh.cu)

2017

Sheila Cabezas a, Sylvia Ho b, Uris Rosa,c, María E. Lanio a, Carlos Alvarez a, F. Gisou van der Goot b, (2017) Damage of eukaryotic cells by the pore-forming toxin sticholysin II: consequences of the potassium efflux Biochimica et BiophysicaActa 1859 982–992 G1 web of science IF: 3.66
Rady J. Laborde, Oraly Sanchez-Ferras, María C. Luzardo, Yoelys Cruz-Leal, Audry Fernández, Circe Mesa, Liliana Oliver, LiemCanet, Liane Abreu-Butin, Catarina V. Nogueira, Mayra Tejuca, Fabiola Pazos, Carlos Álvarez, María E. Alonso, Ieda M. Longo-Maugéri, Michael N. Starnbach, Darren E. Higgins, Luis E. Fernández and María E. Lanio (2017) Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune ResponseJ ImmunolMarch 3, 2017, G1 IF: 5.2
Mesa-Galloso H¹, Delgado-Magnero KH^1,2, Cabezas S¹, López-Castilla A³, Hernández-González JE¹, Pedrera L¹, Alvarez C¹, Peter Tieleman D², García-Sáez AJ⁴, Lanio ME¹, Ros U^1,4, Valiente PA¹ (2017) Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity Protein Sci.2017 Mar; 26(3):550-565. doi: 10.1002/pro.3104. Epub 2017 Feb 23. G1 IF:2.523
Soto C¹, Del Valle A¹, Valiente PA¹, Ros U², Lanio ME¹, Hernández AM³, Alvarez C⁴. Differential binding and activity of the pore-forming toxin sticholysin II in model membranes containing diverse ceramide-derived lipids.Biochimie. 2017 Apr 7. pii: S0300-9084(17)30087- IF:3.113
Emir Salas-Sarduy 1,2,†, Yasel Guerra 1,†,‡, Giovanni Covaleda Cortés 3, Francesc Xavier Avilés 2,3,* and María A. Chávez Planes 1,2,* (2017) Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays Marine drugs . IF: 3.503
Vivian Montero-Alejo;a* Gerardo Corzo; b Javier Porro-Suardíaz; a Zenia Pardo-Ruiz; a Erick Perera; c Leandro Rodríguez-Viera; d Gabriela Sanchez-Díaz; e f ErixWiliam Hernandez-Rodríguez; e, f, Carlos Alvarez; g, Steve Peigneur; h, Jan Tytgat; h, Rolando Perdomo-Morales (2017) Panusin represents a new family of b-defensin-like peptides in invertebratesIn Developmental and Comparative Immunology 67 pp310-321 IF: 3.218
A del Monte-Martínez A, González-Bacerio J, Cutiño-Avila B, Rojas J, Chappé M, Salas-Sarduy E, Pascual I, Guisán JM (2017). Rational design and synthesis of affinity matrices based on proteases immobilized onto cellulose membranes. Prep. Biochem. Biotechnol. 47(8):745-753. IF: 1,361. SJR: 0,395. H: 21.
Doens D, Valiente P A, Mfuh A M, Vo A X T ,Tristan A, Carreno L, Quijada M, Nguyen V T, Perry G, Larionov O V, Lleonart R, Fernandez P L (2017) Identification of inhibitors of CD36-Amyloid beta binding as potential agents for Alzheimer’s disease. ACS Chemical Neuroscience (DOI: 10.1021/acschemneuro.6b00386). IF= 4.348
Hernández González JE, Hernández Álvarez L, Pascutti P G, and Valiente P A (2017) Predicting the binding modes of a series of peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships. Proteins: Structure, Functions and Bioinformatics (DOI: 10.1002/prot.25322). IF= 2.499
Covaleda, Giovanni Trejo, Sebastian A., Salas-Sarduy, Emir, del Rivero, Maday Alonso, Chavez, Maria Angeles, Aviles, Francesc X. (2017) ^a,^⁎NTENSITY FADING MALDI-TOF MASS SPECTROMETRY AND FUNCTIONAL PROTEOMICS ASSIGNMENTS TO IDENTIFY PROTEASE INHIBITORS IN MARINE INVERTEBRATES Journal of Proteomics Volume 165, 8 August 2017, Pages 75-92 IF:3.914
Ahumada, M., Calderon, C., Lissi, E., Alvarez, C., Lanio, M.E., Pazos, F. The pore forming capacity of Sticholysin I in dipalmitoyl phosphatidyl vesicles is tuned by osmotic stress (2017) Chemistry and Physics of Lipids, 203, pp. 87-93. IF:3.361
González-Bacerio J, Maluf SEC, Méndez Y, Pascual I, Florent I, Melo PMS, Budu A, Ferreira JC, Moreno E, Carmona AK, Rivera DG, Alonso del Rivero M, Gazarini ML (2017). KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library. Bioorg. Med. Chem. DOI: 10.1016/j.bmc.2017.06.047. IF: 2,93.
Isel Pascual Alonso, Lotfi Bounaadja, Laura Sánchez, Laura Rivera, Céline Tarnus, Marjorie Schmitt, Gabriela Garcia, Lisset Diaz, Aida Hernandez-Zanuy, Isabelle Florent. (2017) Aqueous extracts of marine invertebrates from Cuba coastline display neutral aminopeptidase inhibitory activities and effects on cancer cells and Plasmodium falciparum parasites. Indian Journal of Natural Products and Resources. 8 (2): 107-119.
Isel Pascual*, Pedro A. Valiente, Gabriela García, Mario E Valdés-Tresanco, Yarini Arrebola, Lisset Díaz, Lotfi Bounaadja, Rosa María Uribe, Mae Chappe, Isabelle Florent, Jean-Louis Charli. Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN). Biochimie BIOCHI-D-17-00200R1-1 DOI information: 10.1016/j.biochi.2017.09.015IF:3.113 Biochimie 142C (2017) pp. 216-225
Otero-Gonzalez AJ, Lopez-Abarrategui C, Garay H, Franco OL, Campos-Dias S, Starnbach M, Wessjohann L and Reguera E (2017) Cm-p5: an antifungal mollusc-derived peptide conjugated with citric acid-modified manganese-ferrite nanoparticles with enhanced activity against Candida albicans in vitro. Journal of Pharmaceutics and Drug Delivery Research. Vol 6 (3, suppl), pag. 79. IF:0.5
González García M., Valdés M., Freitas C., Alba A., López C., San Juan J., Campos S., Luiz Franco O., Otero A. Actividad biológica complementaria in vitro del péptido antifúngico Cm-p5 y predicción in silico de sus regiones funcionales. Revista Cubana de Medicina Tropical. 2017; 69(1) 1-15.
Valdés-Tresanco M E, Valdés-Tresanco M S, Valiente P A, Cocho G, Mansilla R, Nieto-Villar J M (2017) Protein surface roughness accounts for binding free energy of Plasmepsin II‐ligand complexes. J MolRecognit. (DOI: 10.1002/jmr.2661). IF:2.175
Alvarez C, Ros U, Valle A, Pedrera L, Soto C, Hervis P Y, Cabezas S, Valiente P A, Pazos F, Lanio M E (2017) Biophysical and Biochemical Strategies to Understand Membrane Binding and Pore formation by Sticholysins, Pore-Forming Proteins from a Sea Anemone. Biophysical Reviews (DOI: 10.1007/s12551-017-0316-0). IF:0.735
Haydee Mesa Galloso, Karelia H. Delgado-Magnero, Uris Ros, Pedro A. Valiente, D. Peter Tieleman (2017) Dimerization, a Key Step for Pore Formation of Fragaceatoxin C, an Actinoporin from the Sea Anemone Actinia Fragacea, Biophisycal Journal Volume 112, Issue 3, Supplement 1, p524a–525a IF: 3.656
Viviana Falcon, Nelson Acosta-Rivero, Sirenia Gonzalez, Santiago Duenas-Carrera, Gillian Martinez-Donato, Ivon Menendez, Rocio Garateix, Jose A. Silva, Emilio Acosta, Juan Kourı. Ultrastructural and biochemical basis for hepatitis C virus morphogenesis. Virus Genes (2017) 53:151–164. DOI 10.1007/s11262-017-1426. IF:1,431
Viviana Falcón, Nelson Acosta-Rivero, Sirenia González, Santiago Dueñas-Carrera, Emilio Acosta Medina and Juan Kourı. Evidences of ultrastructural remodeling of ER-derived membranes and hepatitis C virus morphogenesis in human liver samples. Revista Cubana Medicina Tropical. Vol 68, N0 3, 2016.
Viviana Falcón, Nelson Acosta-Rivero,Sirenia González, Emilio Acosta Medina, Rocio Garateix Suarez, Jose Ángel Silva, Liz Alvarez-Lajonchere, Gillian Martínez-Donato. Santiago Dueñas. Clustered distribution of virus infected cells in the liver of patients with chronic hepatitis C. Revista Cubana Medicina Tropical. Vol 69, N0 1, 2017.
Falcón-Cama V, Fernández-Mayola M, Mendoza-Mari Y, Acosta-Rivero N, García-Ojalvo A, Bringas-Pérez R, Menéndez-Valdés I, Matos-Terrero M, López-Noudo L, et al. Epidermal Growth Factor based Therapy Promotes Intracellular Trafficking and Accumulation of its Receptor in the Nucleus of Fibroblasts from Diabetic Foot Ulcers. J Diabetic Complications Med (2016) 1, 3: 111.
Guisado-Bourzac, F, Romero del Sol, DL, Guisán Seijas JM, González-Bacerio J, Díaz J, Martins Soares A, del Monte-Martínez A (2017). A two-step purification procedure of phospholipases A2 from the sea anemone Condylactisgigantea. Rev. Cubana Quím. 29(1):133-149. Indizada en SciELO. IF: 0,016
Gabriela Rudd Garcés, María del Carmen Luzardo Lorenzo y Yamila Carpio.González. lnteracción entre el piojo de mar Lepeophtheirus salmonis y sus hospederos: desarrollo de vacunas contra este ectoparásito. Revista Cubana de Ciencias Biológicas, 2017, 5 ( 2): 1-13.

2016

Carlos Lopez-Abarrategui, Viviana Figueroa-Espi, Maria B. Lugo-Álvarez, Caroline D. Pereira, Hilda Garay, Joao A.R.G. Barbosa, Rosana Falcão, Linnavel Jiménez-Hernández, Osvaldo Estévez-Hernández, Edilso Reguera-Ruiz, Octavio L. Franco, Simoni Campos Dias and Anselmo J. Otero-Gonzalez (2016) The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5. International Journal of Nanomedicine, 11: 3849-3857 (WoS, Scopus, FI: 4.32; H: 64; SJR: 1.35).
Ludovico Migliolo, Mário R. Felício, Marlon H. Cardoso, Osmar N. Silva, Mary-Ann E. Xavierd, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi Roca-Subira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J. Otero-Gonzalez, SóniaGonçalves, Nuno C. Santos, Octavio L. Franco (2016) Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2. Biochimica et Biophysica Acta (BBA)–Biomembranes. 1858 (7), Part A: 1488–1498 (WoS, Scopus, FI: 4.64; H: 138; SJR: 1.77).
Yoelys Cruz-Leal, Alejandro López-Requena, IsbelLopetegui-González, Yoan J. Machado Hernández, Carlos Álvarez, Rolando Pérez Rodríguez, María E. Lanio. (2016) Phosphocholine-Specific Antibodies Improve T-Dependent Antibody Responses against OVA Encapsulated into Phosphatidylcholine-Containing Liposomes. Frontiers in Immunology, 7:1-13. (WoS, FI: 5.69, H: 14, SJR: 1,794)
Aymara Cabrera-Muñoz, Laritza Rojas, Maday Alonso-del-Rivero Antigua, José Ricardo Pires (2016). 1-¹H, ¹³C and ¹⁵N resonance assignments and secondary structure analysis of CmPI-II, a serine protease inhibitor isolated from marine snail Cenchritis muricatus. (2016) Biomol NMR Assign 10:1, 153-156 (WoS, FI: 0.687, H: 8, SJR: 0,393)
Aymara Cabrera-Muñoz; Laritza Rojas; Dayrom F Gil; Yamile González-González; Manuel Mansur; AyameyCamejo; Jose Ricardo Pires, Maday Alonso-del-Rivero (2016) Heterologous expression of Cenchritis muricatus protease inhibitor II (CmPI-II) in Pichia pastoris system: purification, isotopic labeling and preliminary characterization. Protein Expression and Purification 126: 127-136. (Scopus, FI: 1.407, H: 62, SJR: 0,721)
Lídice González, Rafael Sánchez, Laritza Rojas, Isel Pascual, Rossana García Fernández, María de los Á. Chávez Planes, Christian Betzel. (2016) Screening of protease inhibitory activity in twenty aqueous extracts of Cuban marine invertebrates. American Journal of Analytical Chemistry, 7, 319-331. (WoS, FI: 1.25, H: 19, SJR: 0,33)
García-Fernández, P. Ziegelmüller, L. González, M. Mansur, R. E. Sánchez, Y. Machado, U. Hahn, M. Á. Chávez. (2016) Expression in Pichia pastoris, purification and characterization of K13L (P1) and Y15S (P2´) mutants of ShPI-1, a protease inhibitor from Stichodactyla helianthus. Prot. Exp. Purif. 123 42-50. (Scopus, FI: 1.407, H: 62, SJR: 0,721)
Wilmer H. Perera Córdova, Suzana Guimarães Leitão, Geraldino Cunha-Filho, Roberto Alonso Bosch, Isel Pascual Alonso, Rogelio Pereda-Miranda, Rodrigo Gervou, Natália AraújoTouza, Luis Eduardo M. Quintas, François Noël. (2016) Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): inhibition of human kidney Na+/K+-ATPase activity. Toxicon 110, 27-34. (WoS, FI: 2,309, H: 88, SJR: 1,008)
Alberto del Monte-Martínez, Jorge González-Bacerio, Bessy Cutiño-Avila, Ritsie Ruiz, Rizette Avila, Miguel Ramos-Leal, Héctor Nolasco, Joaquín Díaz, José M. Guisán (2015). Esters biotransformation by immobilized interfacial esterases from the Caribbean Sea anemone Stichodactyla helianthus. Biotecnología Aplicada. 32:3201-3210. (Scopus, FI: no tiene, H: 8, SJR:0,123)
Rossana García-Fernández, Steve Peigneur, Tirso Pons, Carlos Alvarez, Lídice González, María A. Chávez, and JanTytgat (2016). The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels. Toxins, 8,110. (WoS, FI: 3.571. H: 17, SJR: 1,033).
Valle, Y.P. Hervis, L.B.P. Socas, L. Canet, M. Faheem, J.A.R.G. Barbosa, M.E. Lanio, I.F. Pazos (2016). The multigene families of actinoporins (part II): Strategies for heterologous production in Escherichia coli. Toxicon. 118: 64-81.(WoS, FI: 2.429. H: 88, SJR: 1,008).
Miranda W, Van A N, Valiente PA, Noskov S. (2016) Improved QM/MM Linear Interaction Energy Model for Substrate Recognition in Zinc-Containing Metalloenzymes. Journal of Physical Chemistry B120(32)7824-35. (WoS, FI: 3.187. H: 314, SJR: 1,414)
Guerra Y, Valiente PA, Pons T, Berry C, Rudiño-Piñera R (2016) Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: could the aspartic protease inhibition has evolved from a canonical serine protease-binding loop?Journal of StructuralBiology, 195(2)259-71. (Scopus, FI: 2.570. H: 104, SJR: 2,637)
Montero-Alejo V, Corzo G, Porro-Suardíaz J, Pardo-Ruiz Z, Perera E, Rodríguez-Viera L, Sánchez-Díaz G, Hernández-Rodríguez EW, Álvarez C, Peigneur S, Tytgat J, Perdomo-Morales R. (2016) Panusin represents a new family of β-defensin-like peptides in invertebrates. Dev Comp Immunol. doi: 10.1016/j.dci.2016.09.002(Scopus, FI: 3.620. H: 1,335, SJR: 71)
Frenkel Guisado-Bourzac, Dolores Lázara Romero Del Sol, José Manuel GuisánSeijas, Jorge González-Bacerio, Joaquín Díaz Brito y Alberto del Monte-Martínez. (2016). Obtaining an affinity support for Phospholipase A₂ isolation and purification. Revista Cubana de Química, 28(2)595-609. (Scielo)
Yordanis Pérez-Llano, María del Carmen Luzardo Lorenzo. (2016) Nuevo diseño para una clase práctica de visualización y análisis de la estructura tridimensional de las proteínas. Revista Cubana de Ciencias Biológicas. 5(1)65-70. (Scielo)
Álvarez C y Espinosa G (2016). Transformando la enseñanza experimental de la Bioquímica y la Biología Molecular en la Universidad de La Habana. Breve reflexión y propuestas a propósito del Plan de Estudios E. Revista Cubana de Ciencias Biológicas. 5(1)10-14. (Scielo)
García-Fernández, P. A. Valiente-Flores, C. Alvarez-Valcárcel (2016) Advanced School on Experimental and Bioinformatics Tools for Protein 3D Structure Determination and Analysis. Varadero, Cuba, November, 2015. Crystallographic Meeting Report. IUCr Newsletter 24(1). http://www.iucr.org/news/newsletter
Lanio M.E., Seeger M., Pazos I.F. (2016) Integración del programa de doctorado en Ciencias Biológicas a la Red Iberoamericana de Biotecnología Isla Negra (RIABIN). Revista Cubana de Ciencias Biológicas. 5(1)135-140. (Scielo)
Rojas L., Álvarez M., Francisco Morier L.F., Valdés O., Del Barrio G. (2016) Evaluación preliminar de la actividad antiviral del extracto de Laurencia obtusa frente a herpesvirus y virus dengue. Revista Cubana de Farmacia, 50(1). (Scielo)
Yoelys Cruz Leal, María E. Lanio, et al. (2015) Contribución de las células B-1 a la respuesta de anticuerpos antígeno-especifica y a la polarización del fenotipo de macrófagos peritoneales inducidos por liposomas constituidos por fosfatidil colina. Anales de la Academia de Ciencias de Cuba. Vol. 5, No.3. (Latindex)
Castañeda-Guillot, C. and del Monte-Martínez A. (2015) Prebióticos y sus beneficios en la alimentación. Revista Gastrohnup. 17(3): 18-25. (LILACS, EBSCO)

2014

Cruz-Leal Y, Machado Y, López-Requena A, Canet L, Laborde R, Marcelino Alvares A, Laurindo MF, Santo Tomas JF, Alonso ME, Alvarez C, Arruda R, Popi AF, Mariano M, Pérez R, Lanio ME..2014. Role of B-1 cells in the immune response against an antigen encapsulated into phosphatidylcholine-containing liposomes. Int Immunol PMID: 24618118 (mlanio@fbio.uh.cu)
Cruz-Leal Y, Lucatelli Laurindo MF, Osugui L, Luzardo MD, López-Requena A, Alonso ME, Alvarez C, Popi AF, Mariano M, Pérez R, Lanio ME. 2014. Liposomes of phosphatidylcholine and cholesterol induce an M2-like macrophage phenotype reprogrammable to M1 pattern with the involvement of B-1 cells. Immunobiology. Feb 3. pii: S0171-2985(14)00023-0. doi: 10.1016/j.imbio.2014.01.006. (mlanio@fbio.uh.cu)
Martinez Duniesky a,⇑, Cutino-Avila Bessy b, Perez Enrique Rosendo a, Menendez Carmen, Hernandez Lazaro c, del Monte-Martinez Alberto. 2014. A thermostable exo-b-fructosidase immobilised through rational design Food Chemistry 145 (2014) 826–831. (adelmonte@fbio.uh.cu)
Alberto del Monte-Martinez, Jorge Gonzalez-Bacerio a, Lazara Romero a, Carlos Aragon, Diana Martinez, Maria de los A. Chavez a, Carlos Alvarez a, Maria E. Lanio Jose M. Guisan, Joaquin Diaz. 2014. Improved purification and enzymatic properties of a mixture of Sticholysin I and II: Isotoxins with hemolytic and phospholipase A2 activities from the sea anemone Stichodactyla helianthus Protein Expression and Purification 95 57–66 (adelmonte@fbio.uh.cu)
Javier Alvarado, Yeney Álvarez, Lohans Pedrera, Uris Ros, María E Lanio, Aisel Valle, Carlos Álvarez2 . 2014. Isolation and partial purification of a hemolytic sphingomyelin-inhibitable fraction from the sea anemone Anthopleura nigrescens, Biotecnologia aplicada. 31:53-56 (calvarez@fbio.uh.cu)
Pedrera L, Fanani ML, Ros U, Lanio ME, Maggio B, Alvarez C. 2014. Sticholysin I-membrane interaction: An interplay between the presence of sphingomyelin and membrane fluidity. Biochim Biophys Acta. Mar 26;1838(7):1752-1759(calvarez@fbio.uh.cu)
B. Cutiño-Avila, D. Gil Pradas, C. Aragón Abreu, Y. Fernández Marrero, M. Hernández de la Torre, E. Salas Sarduy, M.A. Chávez Planes, J.M. Guisán Seijas, J. Díaz Brito, A. del Monte-Martínez. 2014. Computer-aided design of bromelain and papain covalent immobilization. Rev. Colomb. Biotecnol. Vol. XVI No. 1, 19-28. (adelmonte@fbio.uh.cu)
Luis Leon Maturana, Eduardo Lissi, Gloria Celedon, Gustavo Gonzalez, Fabiola Pazos, Carlos Alvarez, Maria E. Lanio. 2014. Inactivation of the pore-forming toxin sticholysin I by peroxynitrite. Protection by Cys groups incorporated in the toxin” Protein J. Sep 14. [Epub ahead of print] (mlanio@fbio.uh.cu)
Jorge González-Bacerio, Joel Osuna, Amaia Ponce, Rafael Fando, Katherine Figarella, Yanira Méndez, Jean-Louis Charli, María Á. 2014. High-level expression in Escherichia coli, purification and kinetic characterization of Plasmodium falciparum M1-aminopeptidase. Chávez. Protein Expression and Purification. Volumen 104, , diciembre, pp. 103-114. (jogoba@fbio.uh.cu)
Yanira Méndez, Karell Pérez-Labrada, Jorge González-Bacerio, Gilberto Valdés, María Á de Los Chávez, Joel Osuna, Jean-Louis Charli, Isel Pascual, Daniel G Rivera.2014. Combinatorial Multicomponent Access to Natural-Products-Inspired Peptidomimetics: Discovery of Selective Inhibitors of Microbial Metallo-aminopeptidases ChemMedChem 07/2014; ·doi: 10.1002/cmdc.201402140 (jogoba@fbio.uh.cu)
Yarini M Arrebola, Hansel Gómez, Pedro A Valiente, Maria de los A Chávez, Isel Pascual* .2014. Dipeptidyl peptidase IV and its implication in cancer . Biotecnología Aplicada 31 (2): 102-110 (Isel@fbio.uh.cu)
Yarini M Arrebola, Hansel Gómez, Pedro A Valiente, Maria de los A Chávez, Isel Pascual*. 2014. Dipeptidil peptidasa IV y su implicación en cancer . Biotecnología Aplicada 31 (2): 93-101. (Isel@fbio.uh.cu)
Alba A1, Hernández HM, Marcet R, Gil AL, Vázquez AA, Figueredo M, Sánchez J, Garay HE, 2014. Exploring the antigenic features of Fasciola hepatica rediae (Trematoda: Digenea) through the evaluation of different antigenic candidates for further monoclonal antibody generation. Sarracent J. Parasitol Res. Jun 13.
Jorge González-Bacerio, Rafael Fando, Alberto del Monte, Jean-Louis Charli, María Á. Chávez. 2014. Plasmodium falciparum M1-aminopeptidase: a promising target for the development of antimalarials (Review). Current Drug Targets. EEUU. 15, 1144-1165 (jogoba@fbio.uh.cu)
Carmen Menéndez, Duniesky Martínez, Luis E. Trujillo, Ricardo Ramírez1, Alina Sobrino, Bessy V. Cutiño-Ávila, Liliana Basabe, Alberto del Monte-Martínez, Enrique R. Pérez, Lázaro Hernández. 2014. Development of soluble and immobilized biocatalysts based on a recombinant thermostable b-fructosidase enabling complete sucrose inversion at pasteurization temperatures. Biotecnol. Apl., 31(3), 249-253. ISSN 1027-2852.
Leon, L., E. A. Lissi, Celedón G, Gonzalez G, Pazos F, Alvarez C, Lanio ME. 2014. “Inactivation of the pore-forming toxin Sticholysin I by peroxynitrite: protection by cys groups incorporated in the toxin.” Protein J 33(5): 493-501. (mlanio@fbio.uh.cu)
Maday Alonso-del-Rivero Antigua, María de los Ángeles Chávez Planes, Mey Ling Reytor Gonzalez, Gilberto Valdés, Julieta Delfín Garcia, Joaquin Diaz Brito, Rossana Garcia Fernández, Dagmara Díaz Diaz, Yamile González González. 2014. Una nueva metalocarboxipeptidasa y un nuevo inhibidor bifuncional de serino/metalo proteasas aislados del anélido marino Sabellastarte magnifica: Estructura y función. Revista Anales de la Academia de Ciencias de Cuba. 4 (2): 1-7 (maday@fbio.uh.cu)
Rossana García Fdez, María A. Chávez Planes, Yamile Glez Glez, Tirso Pons Hdez, Dayrom Gil Pradas, Caridad Mireya Romero Tió. 2014. Obtención y caracterización cinética y estructural de dos variantes recombinantes de ShPI-1, inhibidor de proteasas de la anémona Stichodactyla helianthus, y de sus complejos con tripsina, quimotripsina y elastasa. Revista Anales de la Academia de Ciencias de Cuba. 4 (2): 1-7 (Rossana@fbio.uh.cu)
Pedro Alberto Valiente Flores, Tirso Pons Hernández, Alejandro Gil Ley, Yasel Guerra Borrego, Isel Pascual Alonso, Williams Ernesto Miranda Delgado y Yusvel Sierra Gómez. 2014. Análisis in silico de la naturaleza de las interacciones que determinan la especificidad y la selectividad de la plasmepsina II del Plasmodium falciparum por sus sustratos e inhibidores: implicaciones para el diseño de inhibidores más selectivos Revista Anales de la Academia de Ciencias de Cuba. 4 (2): 1-7 (valiente@fbio.uh.cu)
García M de L, Borrero R, Lanio ME, Tirado Y, Alvarez N, Puig A, Aguilar A,Canet L, Mata Espinoza D, Barrios Payán J, Sarmiento ME, Hernández-Pando R, Norazmi MN, Acosta A. Protective effect of a lipid-based preparation from Mycobacterium smegmatis in a murine model of progressive pulmonary tuberculosis. Biomed Res Int. 2014;2014:273129. doi: 10.1155/2014/273129. Epub 2014 Dec 7.PubMed PMID: 25548767; PubMed Central PMCID: PMC4274834 (mlanio@fbio.uh.cu)
Jorge Oscar González Bacerio, UrisLianne Ros Quincoces, Alina Forrellat Barrios. 2014. Enseñanza de la Bioquímica para las carreras de Biología y Microbiología de la Facultad de Biología, Universidad de La Habana, en el Plan de Estudio D. RCCB 3(1): 50 – 58. (jogoba@fbio.uh.cu)
Yarini Manuel Arrebola Sánchez, Lisset Díaz Guevara, Gabriela García Rodríguez, Isel Pascual Alonso. 2014. Dipeptidil peptidasa IV: inhibidores y sus potenciales aplicaciones biomédicas / Dipeptidil peptidase IV: inhibitors and potentials biomedical applications RCCB 3(2) : 14-26. (Isel@fbio.uh.cu)
Yadira de la Patria Hervis Valdés, Aisel Valle Garay, Liem Canet Santos, Carlos Manuel Álvarez Valcárcel, María Eliana Lanio Ruiz, Isabel Fabiola Pazos Santos. 2014. Importancia funcional de la Pro80 para la interacción con membranas y la formación de poros por la sticholysina I, actinoporina de Stichodactyla helianthus (Anthozoa: Stichodactylidae) RCCB 3(2) : 27-40 (fpazos@fbio.uh.cu)
Del Monte Martinez A., Cutiño Avila B., Gonzalez Baceiro J., Chaves MA., Diaz J. . 2014. Diseño Racional en la inmovilización de proteínas: aplicaciones en afinidad y en bioconversion de proteínas Revista Anales de la Academia de Ciencias de Cuba Vol 4 No1 pp G2 scielo (adelmonte@fbio.uh.cu)
María Eliana Lanio, Fabiola Pazos, Rosangela Itri, Shirley Schreier, Luis E. Fernández, Carlos Álvarez Proteínas Formadoras de Poros de Stichodactyla helianthus y sus Aplicaciones en la Biomedicina. pp. 37-57. En “Temas seleccionados de toxinas con implicaciones biomédicas y métodos para su estudio” (calvarez@fbio.uh.cu)
Rodrigo Montecinos, Eduardo Lissi, Carlos Alvarez, María Eliana Lanio, Fabiola Pazos Interactions of Sticholysin I with DPPC/SM bilayers. A Molecular Dynamics study.. PP.96-113. En “Temas seleccionados de toxinas con implicaciones biomédicas y métodos para su estudio”. (fpazos@fbio.uh.cu)

2013

Hansel Gómez, Mae Chappé , Pedro Valiente, Tirso Pons, María de los Angeles Chávez , Jean-Louis Charli and IselPascual (2013) Effect of zinc and calcium ions on the rat kidney membrane-bound form of dipeptidyl peptidase IV. Journal of Biosciences.38.3: 1-9 ()
Ros U., Edwards M.A, Epand R.F., Lanio M.E., Schreier S., Yip C.M., Alvarez C., Epand R.M. The sticholysinfamily of pore-forming toxins induce the mixing of lipids in membrane domains. (2013). Biochimica et Biophysica Acta 1828. 2757.2762.()
Ros U., Souto A.L., de Oliveira F.L, Crusca E.J., Pazos, F., Cilli E.M., Lanio, M.E., Schreier, S., Alvarez, C. Functional and topological studies with Trp-containing analogs of the peptide StII1-30 derived from the N-terminus of the pore forming toxin sticholysin II: contribution to understand its orientation in membrane. (2013). Biopolymers (Peptide Science) 100 (4): 337-346 ()
López-Abarrategui, C; Figueroa-Espí, V; Reyes-Acosta, O; Reguera, E; Otero-González, AJ (2013) Magnetic nanoparticles: New players in antimicrobial peptide therapeutics. Current Protein and Peptide Science, vol 14(7): Aug 2. [Epub ahead of print] ()
López-Abarrategui C. and Otero-González AJ. (2013) Subcellular proteomics for understanding Host Defense Peptides mechanism of action.Review article. Organelles Proteomics, 1: 7-15. DOI: 10.2478/orpr-2013-0003 . ORPR . 2013 . 7.15 No (Número inicial) ()
Loiane Lima, Ludovico Migliolo, Clovis Castro, Debora Pires, Carlos Lopez-Abarrategui, Eveline Gonçalves, Ilka Vasconcelos, Jose Oliveira, Anselmo Otero-Gonzalez, SimoniDias and Octavio L. Franco (2013) Identification of a Novel AntimicrobialPeptidefromBrazilianCoast Coral Phyllogorgiadilatata. Protein & Peptide Letters, 20(10): 1153.158. ()
B. Cutiño-Avila, E. Cunill-Semanat, D.F. Gil, M.A. Chávez, J. Díaz, A. del Monte-Martínez.Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design. In: V Latin American Congress on Biomedical Engineering CLAIB 2011, IFMBE Proceedings Volume 33, José Folgueras Méndez, Tania Y. Aznielle Rodríguez, Carlos F. CalderónMarín, Susana Beatriz Llanusa Ruiz, Jorge Castro Medina, Haddid Vega Vázquez, MaylenCarballoBarreda, Rafael Rodríguez Rojas (Eds.), (2013) pp 160-163. Print ISBN 978-3-642-21197-3, Online ISBN 978-3-642-21198-0, Series ISSN 1680-0737, Springer Science+Business Media Berlin Heidelberg, DOI 10.1007/978-3-642-21198-0_41.()
A.del Monte-Martínez, B. Cutiño-Avila, D. Gómez, I. Pereda, J. Díaz, J. Rojas. Computational mathematic model for the immobilization of cells and proteins on charged solid surfaces by electrostatic interactions. In: V Latin American Congress on Biomedical Engineering CLAIB 2011, IFMBE Proceedings Volume 33, José Folgueras Méndez, Tania Y. Aznielle Rodríguez, Carlos F. CalderónMarín, Susana Beatriz Llanusa Ruiz, Jorge Castro Medina, Haddid Vega Vázquez, MaylenCarballoBarreda, Rafael Rodríguez Rojas (Eds.), (2013) pp 73-76. Print ISBN 978-3-642-21197-3, Online ISBN 978-3-642-21198-0, Series ISSN 1680-0737, Springer Science+Business Media Berlin Heidelberg, DOI 10.1007/978-3-642-21198-0_19.()
Borrero R., García M.A., Canet L., Zayas C., Reyes F., Prieto J.L., Infante J. F., Lanio M.E., Kadir R., López Y., Sarmiento M. E., Norazmi M. N., Acosta A. Evaluation of the humoral immune response and cross reactivity against Mycobacterium tuberculosis of mice immunized with liposomes containing glycolipids of Mycobacterium smegmatisBMC Immunology 2013, 14(Suppl 1), S13, 1-4. ()
Evaluation of specific humoral immune response and cross reactivity against Mycobacterium tuberculosis antigens induced in mice immunized with liposomes composed of total lipids extracted from Mycobacterium smegmatis.García M.A., Borrero R., Marrón R., Lanio M.E., Canet L., Otero O., Kadir R., Suraiya S., Zayas C., López Y., Norazmi M. N., Sarmiento M. E., Acosta A. BMC Immunology 2013, 14(Suppl 1), S11, 1-5. ()
Perez-Riverol Y, Hermjakob H, Kohlbacher O, Martens L, Creasy D, Cox J, Leprevost F, Shan BP, Pérez-Nueno VI, Blazejczyk M, Punta M, Vierlinger K, Valiente PA, Leon K, Chinea G, Guirola O, Bringas R, Cabrera G, Guillen G, Padron G, Gonzalez LJ, Besada V. (2013) ComputationalProteomicsPitfalls and Challenges: HavanaBioinfo 2012 WorkshopReport. J Proteomics.2013 Jan 29.doi:pii: S1874-3919(13)00049-3. ()
Alonso-del-Rivero M., ReytoR ML., Trejo SA., Chávez MA., Avilés FX., and Reverter D. (2013) A novel and non-canonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the tri-KunitzSmCI in complex with human CPA4. Structure21, 1118.1126 ()
Emir Salas Sarduy; Aymara Cabrera-Muñoz; Ana Cauerhff; Yamile González-González; Sebastián A Trejo; Agustina Chidichimo; Maria A Chávez Planes; Juan J Cazzulo (2013). Antiparasitic effect of a fraction enriched in tight-binding protease inhibitors isolated from the Caribbean coral Plexaurahomomalla. Experimental ParasitologySep 30. pii: S0014-4894(13)00258-0. doi: 10.1016 ()
Ros U., Pedrera L., Martínez D., Tejuca M., Pazos F., Lanio M.E., Alvarez C. Synthetic peptides that reproduce the N-terminus of sticholysins as models for the study of their structure-function relationship. (2013). Biotecnología Aplicada 30(4): 1-5()
Alberto del Monte-Martínez, Bessy V. Cutiño-Avila, Jorge O. González-Bacerio, Darío González-Abradelo, Viviana Figueroa Espí y Roberto Cao-Vázquez. Aplicación de enzimas en biocatálisis. Perspectivas de la utilización de nanoarreglos como biocatalizadores. REVISTA CUBANA DE CIENCIAS BIOLÓGICAS. (2013) Vol. 2 (2): 7-23. Rnps: 2362 . ISSN: 2307-695X. ()
Pentón-Madrigal, A., Estevez-Rams, E,. Reguera, E., Rodríguez-Hernández, J. Concepción-Rosabal, B., García-Basabe, Y., García-Fernández, R., Talavera, A., Moreno, E. (2013) A decade of Cuban presence in Synchrotronlighsourcefacilities. Rev. Cub. Fis. 30, 36-41. ()
Yamilé González, Dayrom Gil, Maday Alonso del Rivero, Isel Pascual, Rossana García, Julieta Delfín, Joaquín Díaz, Mariana S. Araujo, Aparecida S. Tanaka, Tirso Pons y María A. Chávez (2013) Inhibidores de serino proteasas de naturaleza proteica aislados de invertebrados marinos. Revista Cubana de Ciencias Biológicas. 2(1):5-13 ()
Maday Alonso del Rivero, Yamilé González, Isel Pascual, Rossana García, Julieta Delfín, Joaquín Díaz y María A. Chávez (2013) Multifunctionalproteasesinhibitors of proteicnature. Revista Cubana de Ciencias Biológicas.2(1):14-21 ()

2012

1. Oliveira-Santos J, Nunes VA, Cruz-Silva I, Praxedes-Garcia P, Gozzo AJ, Rydlewski M, González-González Y, Nader HB, Araujo MS (2011) GlycosaminoglycansModifyelastaseAction In Vitro and EnhanceElastase-InducedCellDeath in CulturedFibroblastsCellBiologyVol 2012G1 web of Science ()
2. Lovato DV. , Amino R, González Y, Miranda A, Schenkman S, Tanaka AS (2011) Infestin 1R, an intestinal subtilisin inhibitor from Triatoma infestans able to impair mammalian cell invasion by Trypanosoma cruziExp. Parasitology 129: 362.367(IF: 2.212) Scopus. G1 ()
3. López-Abarrategui, C., Alba-Menéndez, A., Silva, ON, Reyes- Acosta, O., Vasconcelos, IM., Abreu de Oliveira, JT., Migliolo, L., Costa, MP, Costa, CR., Silva, MRR, Garay, HE, Dias, SC, Franco, OL and Otero-González, AJ. (2012) Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritismuricatus. Biochimie, 94: 968-974 (IP: 3.78, G1), MedLine, Web of Science. ()
4. Annia Alba, Carlos López-Abarrategui, Anselmo J. Otero-González (2012) Host DefensePeptides: A TherapeuticAlternative As AntiiInfectiveDrugs And ImmunomodulatoryTherapeutics. Biopolymers: Peptide Sciences 98(4): 251-267 (IP: 2.55, G1), MedLine, Web of Science. ()
5. Carlos López-Abarrategui, Annia Alba-Menéndez, Loiane A. Lima1, Simone Maria-Neto, Ilka M. Vasconcelos, Jose T. A. Oliveira, Simoni C. Dias, Anselmo J. Otero-Gonzalez and Octavio L. Franco (2012) Screening of antimicrobials from Caribbean sea animals and isolation of bactericidal proteins from the littoral mollusk Cenchritismuricatus. Current Microbiology64: 501-505 (IP: 1.81, G1), MedLine, Web of Science. ()
6. Silva, ON., Mulder, KCL., Barbosa, AEAD, Otero-Gonzalez, AJ, Lopez- Abarrategui, C., Rezende, TMB. Dias, SC and Franco, OL (2011) Exploring the pharmacological potential of promiscuous host defense peptides: from natural screenings to biotechnological applications. Frontiers in Microbiology, 2: 1-14 (IP: 1.08, G1), MedLine, Web of Science. ()
7. Simone Maria-Neto, Elizabeth Candido, Diana Ribas, Daniel Souza, Ezequiel Silva, Lidia Pepe, Anselmo Otero-González, Beatriz Magalhães, Simoni Dias, and Octávio Franco. Deciphering the magainin-resistance process of Escherichia coli strains in light the cytosolic proteome (2012) Antimicrobial Agents and Chemotherapy. 56(4): 5558-11. (IP: 4.84, G1), MedLine, Web of Science. ()
8. Alonso-del-Rivero M, Trejo SA, Reytor ML, Rodriguez-de-la-Vega M, Delfin J, Diaz J, González-González Y, Canals F, Chavez MA, Aviles FX. (2012) Tri-domain bifunctional inhibitor of metallocarboxypeptidases A and serine proteases isolated from marine annelid Sabellastartemagnifica.J Biol Chem. 2012 May 4;287(19):15427-38. Epub 2012 Mar 12(IP: 4.773, G1) MedLine, Web of Science. ()
9. Sarduy ES, Muñoz AC, Trejo SA, Chávez Planes MA. (2012) High-level expression of Falcipain- 2 inEscherichia coli by codon optimization and auto-induction. ProteinExpression and Purification; 83(1):59-69 (IP: 1.587, G1) web of Science (mchavez@infomed.sld.cu) ()
10. Giovanni Covaleda, Maday Alonso del Rivero, María A. Chávez, Francesc X. Avilés, and David ReverterCrystal Structure of Novel Metallocarboxypeptidase Inhibitor from Marine Mollusk Neritaversicolor in Complex with Human Carboxypeptidase A4 J. Biol. Chem. 2012 287:9250-9258.First Published on January 31, 2012, doi:10.1074/jbc.M111.330100(IP: 4.773, G1) MedLine, Web of Science. ()
11. Sarduy ES,Chávez Planes MA. Efficient expression systems for cysteine proteases of malaria parasites: too good to be true? Bioengineered. 2012 Sep 27;4(2). [Epubahead of print] ()
12. Ros U., Pedrera L., Diaz D., de Karam J.C., Sundbrack T.P, Valiente, P.A., Martínez, D., Cilli, E.M., Pazos, F., Itri, R., Lanio, M.E., Schreier, S., Alvarez, C. (2011). The membranotropic activity of N-terminal peptides from the pore-forming proteins sticholysin I and II is modulated by hydrophobic and electrostatic interactions as well as lipid composition. J. Biosci. 36 (5): 781-791. (FI:1.9)G1 web of Science ()
13. A. del Monte-Martínez and B.V. Cutiño-Avila. Rational design of immobilized lipases and phospholipases, J. Meth. Mol. Biol. 861(2012) 343.82. Impact Factor: 13.9 G1, Web of Science ()
14. García-Fernández R, Pons T, Perbandt M, Valiente P.A, Talavera A, González Y., Rehders D, Chávez M. A, Betzel Ch, Redecke, L. Structuralinsightsintoserineproteaseinhibitionby a marine invertebrateKunitz-typeinhibitor. J. Struct. Biol. (2012) En prensa (http://dx.doi.org/10.1016/j.jsb.2012.08.009). IF 3.406, Scopus. G1 ()
15. Bernardo L., Pavón A., Hermida L., Gil L., Valdés I., Cabezas S., Linares R., Alvarez M., Silva R., Guillén G., Nagy E., Schlick P., Guzmán MG. The two component adjuvant IC31(®) potentiates the protective immunity induced by a dengue 2 recombinant fusion protein in mice. Vaccine. 2011; 29: 4256-63. GRUPO 1. WEB OF SCIENCE Web of Science, ELSEVIER, ISSN 0264-410X. IF: 3.766G1 ()
16. Guerra Y, Valiente PA, Berry C, and Pons T (2012) Predicting functional residues of the Solanumlycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking. Journal of Molecular ModelingVol 18 (6): 2673-2687. Web of Science(FI= 2.184)G1 ()
17. G Ramos Echazábal, G Chinea, R García-Fernández, T Pons (2012) In silico studies of potential phosphoresidues in the human nucleophosmin/B23: its kinases and related biological processes Journal of Cellular Biochemistry 113 (7), 2364-2374 FI: 2.868 G1. Web of Science ()
18. García-Fernández R, Pons T, Meyer A., Perbandt M, González Y., Gil D, Chávez M. A, BetzelCh, Redecke, L. Crystal structure of the recombinant BPTI-Kunitz type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus. ActaCryst. F. (2012) Aceptada. IF 0.51, indexada enScopus. DOI:10.1107/S1744309112039085 ()
19. Alberto del Monte-Martínez, Jorge González-Bacerio, Carlos Aragón-Abreu, JoséMiguel Palomo-Carmona, José Manuel Guisán-Seijas and Joaquín Díaz-Brito. Selective and oriented immobilization of (phospho)lipases from the Caribbean Sea anemone Stichodactylahelianthus(Ellis, 1768) by interfacial adsorption.Revista CENIC Ciencias Biológicas, Vol. 43 (2012), No. 1, p. 3-8.LATINDEX, Chemical Abstract, ILA, EBSCOG2 ()
20. Jorge Oscar González-Bacerio, Gilberto Valdés García, Amaia Ponce de la Cal, Anett Rubio Torres, Sandra Madariaga Zarza, María de los Ángeles Chávez Planes, Isel Pascual Alonso La investigación científica en el campo de la malaria, importancia socioeconómica y ética. Panorama Cuba y Salud. Vol. 7., No. 3, año 2012, septiembre-diciembre, pp: 28-36, Cuba. ()

Estructuras anotadas en la base de datos “Protein Data Bank” (2 estructuras anotadas)

Crystal structure of the Kunitz-type protease inhibitor ShPI-1 Lys13Leu mutant in complex with pancreatic elastase’ (2012). Rossana García-Fernández, Markus Perbandt, Dirk Rehders, Yamile González, María de los Ángeles Chávez, Patrick Ziegemüller, Nicolas Piganeau, Ulrich Hahn, Christian Betzel, Lars Redecke. PDB ID: 3UOU. ()
Structure of the carboxypeptidase inhibitor from the snail Neritaversicolor in complex with human CPA4 G. Covaleda, M Alonsodel Rivero, MA, Chavez, FX Avilés, D. Reverter (2011) PDB code: 4a94 ()

2011

1. Ley AG, Valiente P A, Pascutti PG, and Pons T (2011) Computational Perspectives into Plasmepsins Structure-Function Relationship: Implications to Inhibitor Design. Journal of Tropical Medicine Vol 2011: 657483 (FI=no reportado en 2010 en el sitio del ISI) PUBMED ID: 21760810. ()
2. V. Figueroa-Espí, A. Alvarez-Paneque, M. Torrens, A.J. Otero-González, E. Reguera (2011) Conjugation of manganese ferrite nanoparticles to an anti Sticholysin monoclonal antibody and conjugate applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol 387(1-3): 118-124. ()
3. Torres-Salas P, del Monte-Martínez A, Cutiño-Avila B, Rodríguez-Colinas B, Alcalde M, Ballesteros AO, Plou FJ. (2011) Immobilized Biocatalysts: Novel Approaches and Tools for Binding Enzymes to Supports. Advanced Materials XX: 1-8. DOI: 10.1002/adma.201101821. ()
4. Isel Pascual, Hansel Gómez, Tirso Pons, Mae Chappé, Miguel Angel Vargas, Gilberto Valdés, Alí Lopéz, Angélika Saroyán, Jean-Louis Charli, María de los Angeles Chávez. (2011) Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV. International Journal of Biochemistry and Cell Biology. 43, 363.371 ()
5. Gil, D., Garcia-Fernandez, R., Alonso-del-Rivero, M., Lamazares, E., Perez, M., Varas, L., Diaz, J., Chavez, M. A., González-González, Y., Mansur, M. (2011). Recombinant expression of ShPI-1A, a non-specific BPTI-Kunitz-type inhibitor, and its protection effect on proteolytic degradation of recombinant human miniproinsulin expressed in Pichia pastoris. FEMS Yeast Res. Vol 11:7 575-586. ()
6. Pentón, David; Pérez-Barzaga, Victor; Díaz, Iscel; Reytor, Mey; Campos, Javier; Fando, Rafael; Calvo, Loany; Cilli, Eduardo; Morera, Vivian; Castellanos-Serra, Lila; Pazos, Fabiola; Lanio, María; Álvarez, Carlos; Pons, Tirso; Tejuca, Mayra (2011). Validation of a mutant of the pore-forming toxin sticholysin-I for the construction of proteinase-activated immunotoxins. Protein Engineering, Design, and Selection XXX :1-9, doi:10.1093/protein/gzr002). ()
7. Garay H, Menéndez T, Cruz-Leal Y, Coizeau E, Noda J, Morera V, Guillén G, Albericio F, Reyes O. (2011) Study of various presentation forms for a peptide mimetic of Neisseria meningitidis serogroup B capsular polysaccharide. Bioconjug Chem. Jan 19; 22(1):33-41. PMID:21141955] ()
8. Valle A, López-Castilla A, Pedrera L, Martínez D, Tejuca M, Campos J, Fando R, Lissi E, Alvarez C, Lanio ME, Pazos F, Schreier S. (2011) Cys mutants in functional regions of Sticholysin I clarify the participation of these residues in pore formation. Toxicon. Jul;58(1):8-17. Epub 2011 Apr 13. PubMed PMID: 21510967. ()
9. Celedón G, González G, Lissi E, Cerda T, Bascuñant D, Lepeley M, Pazos F, Lanio ME, Alvarez C. (2011). Effect of pre-exposure of human erythrocytes to oxidants on the haemolytic activity of Sticholysin II. A comparison between peroxynitrite and hypochlorous acid. Free Radic Res. 45(4):400-8 ()
10. del Monte-Martínez A, Cutiño-Avila B, Gómez D, Pereda I, Díaz J, Rojas J. (2011) Computational mathematic model for the immobilization of cells and proteins on charged solid surfaces by electrostatic interactions. In: IFMBE Proceedings Vol 33. 1st Edition, 800 p. Folgueras J, Aznielle TY, Calderón CF, Llanusa SB, Castro J, Vega H, Carballo M, Rodríguez R (Eds.). Softcover, ISBN 978-3-642-21197-3. Springer Science+Business Media. ()
11. Cutiño-Avila B, Cunill-Semanat E, Gil DF, Chávez MA, Díaz J, del Monte-Martínez A. (2011) Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design. In: IFMBE Proceedings 33. 1st Edition, 800 p. Folgueras J, Aznielle TY, Calderón CF, Llanusa SB, Castro J, Vega H, Carballo M, Rodríguez R (Eds.)., Softcover, ISBN 978-3-642-21197-3. Springer Science+Business Media ().
12. López, A.; Valle, A.; Pedrera, L.; Martínez, D.; Fando, R.; Schreier, S.; Álvarez, C.; Lanio, M.E. y Pazos, F. (2011) The Sticholysin I mutants St I E2C and St I R52C show similar binding to liposomal vesicles but differ in their permeabilizing activity. Biotecnología Aplicada. 28 (1) 2011. ()
13. Alba-Menéndez,A., López-Abarrategui, C., Vázquez-Perera,AJ., Otero- González, AJ (2011) Optimización de la solución de extracción de moléculas antibacterianas de Cenchritis muricatus (Gastropoda: Littorinidae). Rev Cub Med Trop 63(2):171-6 ()
14. Gonzalez-Gonzalez Y., Gil D., Alonso-del-Rivero M., Besada V., Gil J., Araujo MS., Tanaka., AS., Pons T., Chavez MA. (2010) Novel protease inhibitors active against human neutrophil elastase and plasma kallikrein with therapeutic potentialities: Structure-function relationships. Biotecnología Aplicada 27 (4): 310-313. ()
15. Mey Ling Reytor, Yamile González, Isel Pascual, Aida Hernández, María Á Chávez, Maday Alonso del Rivero (2011) Screening of protease inhibitory activity in extracts of five Ascidian species from Cuban coasts. Biotecnología Aplicada 28 (2):77-82 ()
16. Carol Carvajal, Margarita Márquez, Aurora T. Pérez, María de los A. Chávez, Martha Hernández. (2010) Caracterización cinética de un preparado semipurificado de bromelina para su uso como antitumoral.. Revista Cubana de Plantas Medicinales, Vol. 15, No. 2, 2010. ()
17. María A. Chávez Planes, Joaquín Díaz Brito, María E. Lanio Ruiz y Carlos M. Álvarez Valcárcel (2011). El Centro de Estudio de Proteínas de la Universidad de La Habana: contribución científica y compromiso social. Revista Universidad de La Habana, No 270()
18. Álvarez C, Alonso-del-Rivero M, Hernández A, Díaz J, Lanio ME, Chávez MA. (2010). Biomoléculas de interés biomédico y biotecnológico a partir de organismos marinos: la perspectiva del Centro de Estudio de Proteínas de La Universidad de La Habana. En: La biodiversidad en ecosistemas marinos y costeros del litoral de Iberoamérica y el cambio climático: Memorias del Primer Taller de la Red CYTED BIODIVMAR. pp: 221-233.

Estructuras anotadas en la base de datos “Protein Data Bank”

PDB ID: 3T62 (2011) R. Garcia-Fernandez, R. Dominguez, D. Oberthuer, T.Pons, Y.Gonzalez-Gonzalez, M. A. Chavez, C. Betzel, L. Redecke: Crystal structure of recombinant Kunitz type serine protease inhibitor-1 from the caribbean sea anemone Stichodactyla helianthus in complex with bovine chymotrypsin (2011).

2010

Otero-González AJ, Simas Magalhães B, Garcia-Villarino M, López-Abarrategui C, Amaro Sousa D, Campos Dias S, Luiz Franco O. (2010) Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control. FASEB Journal 2010; 0: fj.09-143388v2 ()
Otero-González AJ, Simas Magalhães B, Garcia-Villarino M, López-Abarrategui C, Amaro Sousa D, Campos Dias S, Luiz Franco O. (2010) Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control. FASEB Journal, 24, 1320-1334 (FI: 7.12) MEDLINE, WEB of Science)
Lazara Romero, Silvana Marcussi, Daniela P. Marchi-Salvador, Floriano P. Silva Jr., André L. Fuly, Rodrigo G. Stábeli, Saulo L. da Silva, Jorge González, Alberto del Monte, Andreimar M. Soares. (2010) Enzymatic and structural characterization of a basic phospholipase A2 from the sea anemone Condylactis gigantea. Biochimie 92:1063-1071.(FI: 3.897) Indexada en la web of Sciences.
Jorge González-Bacerio, Jairo Rodríguez Hernández, Alberto del Monte Martínez. (2010). Lipases: enzymes having the potential for developing immobilised biocatalysts by interfacial adsorption. Rev. Colomb. Biotecnol. Vol. XII No. 1,124-140. Indexada en la web of Sciences. (REDALYC, LILACS, DIALNET, CAB, Swets Information Services B.V, INIST, DOAJ, Scielo, EBSCO).
García T, Martinez D, Palmero A, Soto C, Tejuca M, Pazos F, Menéndez R, Alvarez C, Garateix A Pharmacological effects of two cytolysins isolated from the sea anemone Stichodactyla helianthus.. J Biosci. 2009 34(6):891-8. Web of Science IF: 1.703 referenciado en PubMed/Medline, Springer.
Garcia-Fernandez, R., Redecke, L., Pons, T., Perbandt, M., Talavera, A., Gil, D., Gonzalez, Y., de los Angeles Chavez, M., Betzel, C (2010). Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Carribean sea anemone Stichodactyla helianthus. PDB 3OFW.
Garcia-Fernandez, R., Redecke, L., Pons, T., Perbandt, M., Gil, D., Manzur, M., Gonzalez, Y., de los Angeles Chavez, M., Betzel, C (2010). Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Caribbean sea anemone Stichodactyla helianthus in complex with bovine pancreatic trypsin. PDB: 3M7Q.
Valiente PA, Ley AG, Batista PR, Caffarena ER, Pons T, Pascutti PG. (2010) New parametrization approaches of the LIE method to improve free energy calculations of PlmII-Inhibitors complexes. Journal of Computational Chemistry 31(15): 2723-34. (FI=3.769), PUBMED ID: 20839299.
Perera E, Pons T, Hernández D, Moyano FJ, Martínez-Rodríguez G, Mancera JM. (2010) New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket. FEBS J. 277(17):3489-3501. (FI: FI: 3.042). PUBMED ID: 20649906.
Ruiz-Peña M, Oropesa-Núñez R, Pons T, Renaux-Louro S, Pérez-Gramatges A. (2010) Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin. Colloids Surf. B: Biointerfaces 75(1):282-9. (FI: 2.600). PUBMED ID: 19782541
Otero AJ (2010) Los anticuerpos y su rol como herramientas analíticas en los ensayos inmunoensayos enzimáticos. Rev Cub Med Trop. 62(2): 85-92. (MEDLINE, Scielo)
Otero AJ. (2010) Los inmunoensayos enzimáticos para detectar agentes infecciosos o sus productos: Algunos diseños y aplicaciones. Rev Cub Med Trop. 62(3): 167-179 (MEDLINE, Scielo)
Gladys Margarita Lugioyo, Orquídea Coto, Carlos Álvarez and Georgina Espinosa (2010). Revista Ciencias Marinas y Costeras Vol 2, pag 65-77 Bacillus species in the oceanic waters adjacent to Cuba: association between their distribution and metabolic activity., (REVMAR, ISSN 1659-455X versión, impresa, ISSN 1659-407X versión digital)
Odalys Blanco H., Yuliannis Lugones L, Dayrom F. Gil P, Roberto Faure, Yamile González G. (2009) Human neutrophil elastase and lung surfactant in acute respiratory distress syndrome. Biotecnología Aplicada 2009; 26:1-6.
María V. Mederos, Mayra Tejuca, Emir Salas, María de los A. Chávez (2010) Estrategia de cómputo para la resolución de modelos biológicos no lineales. Revista Investigación Operacional Vol 31 No2 pag 281-286
Carol Carvajal; Margarita Márquez; Aurora T. Pérez; María de los A. Chávez y Martha Hernández (2010) Caracterización cinética de un preparado semipurificado de bromelina para uso antitumoral Revista Cubana de Plantas Medicinales.15(2).
Luzardo MC, Gomes E, Faustino L, Sanchez O, Laborde R, Cruz-Leal Y, Canet L, Alvarez C, Alnso ME, Lanio ME, Russo M (2010). Immunomodulatory properties of liposomes and Sticholysin II in a murine model of asthma. VacciMonitor 19(1): 24. ISSN 1025-028X, EISSN 1025-0298 (SCIELO) (IF= 1.231)
Laborde R, Sánchez O, Luzardo MC, Cruz-Leal Y, Canet L, Valle A, Oliver L, Fernández A, Mesa C, Hernández I, Pazos F, Tejuca M, Alvarez C, Alonso ME., Fernández LE., Lanio ME. (2010). Stimulation of cellular immune response by Liposomes encapsulating Sticholysins, pore-forming toxins from the anemone Stichodactyla helianthus. VacciMonitor 19(1): 34. ISSN 1025-028X, EISSN 1025-0298 (SCIELO) (IF= 1.231)
Cruz-Leal Y, Machado Y, Sánchez O, Luzardo MC, Canet L, Laborde R, Requena A, Oliver L, Castillo A, de la Luz KR, Alonso ME, Álvarez C, Pérez R, Lanio ME. (2010) B-1 Cells modulate the antibody response induced by an antigen encapsulated in Phosphatidylcholine:Cholesterol liposomes VacciMonitor Vol. 19 Supplement 1: 34. ISSN 1025-028X, EISSN 1025-0298 (SCIELO) (IF= 1.231)
Borrero R, García MA, Canet L, Zayas C, Reyes F, Prieto J, Infante JF, Lanio ME, Sarmiento ME, Mohd N and Acosta A. (2010) Evaluation of the humoral immune response and Cross reactivity against mycobacterium tuberculosis of Liposomes containing glycolipids of Mycobacterium smegmatis. VacciMonitor Vol. 19 Supplement 1: 24. ISSN 1025-028X, EISSN 1025-0298 (SCIELO) (IF= 1.231)
Alberto del Monte Martínez, Bessy Cutiño-Avila, Dayrom Francisco Gil Pradas, Leonardo Mokarzel Falcón, Jorge González Bacerio, Mario Pupo Meriño, María A. Chávez Planes, Tirso Pons Hernández, Joaquín Díaz Brito (2010). Estrategia de Diseño Racional en la Síntesis de Derivados Inmovilizados. Su implementación mediante el programa RDID1.0. Memorias UCIENCIA 2010. VI Taller de Bioinformática. ISBN 97S-959-2S6-011-7.
del Monte-Martínez Alberto, Cutiño-Avila Bessy, Gil Dayrom F., Mokarzel Leonardo, González-Bacerio Jorge, Pupo Mario, Chavez María A., Pons Tirso and Díaz Joaquín. (2010). Advance on the Rational Design of Immobilized Derivatives. RDID Strategy. Memorias IV Simposium Internacional de Química. ISBN 978-959-250-566-7.
Cutiño-Avila Bessy, Gil Dayrom F., González-Bacerio Jorge, Mokarzel-Falcón Leonardo, Chavez María A., Díaz Joaquín and del Monte-Martínez Alberto. Algorithm development for protein ionizable group’s reactivity on covalent immobilization. Memorias IV Simposium Internacional de Química. ISBN 978-959-250-566-7.

2009

Alonso-del-Rivero, M., Trejo, SA., Rodríguez-de-la-Vega, M., González, Y., Bronsoms S., Canals, F., Delfín, J., Díaz, J., Avilés F.X., Chávez M.A (2009) A novel metallocarboxypeptidase like enzyme isolated from the marine annelid Sabellastarte magnifica- A step into the invertebrate world of proteases. FEBS Journal 276, 4875-4890 .
Álvarez C, Mancheño JM, Martínez D, Tejuca M, Pazos F, Lanio ME (2009). Sticholysins, two pore-forming toxins produced by the Caribbean Sea anemone Stichodactyla helianthus: Their interaction with membranes. Toxicon 54, 1135-47 .
Ramírez AR, Guerra Y, Otero A, García B, Berry C, Mendiola J, Hernández-Zanui A, Chávez MA. (2009) Generation of an affinity matrix useful in the purification of natural inhibitors of plasmepsin II, an antimalarial-drug target. Biotechnol Appl Biochem. 52: 149-57.
Celedón G, González G, Lissi E, Cerda T, Martínez D, Soto C, Pupo M, Pazos F, Lanio ME, Álvarez C (2009). Effect of calcium on the hemolytic activity of Stichodactyla helianthus toxin sticholysin II on human erythrocytes. Toxicon 54, 845-50 .
Tejuca M, Anderluh G and Dallaserra M. (2009). Sea anemone cytolysins as toxic components of immunotoxins. Toxicon 54:1206-14
Sánchez E, Vargas MA, Singru PS, Pascual I, Romero F, Fekete C, Charli JL, Lechan RM. (2009) Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence. Endocrinology 150: 2283-91
Ruiz-Peña M, Oropesa-Núñez R, Pons T, Renaux-Louro S, Pérez-Gramatges A. (2009) Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin. Colloids Surf. B: Biointerfaces. (doi: 10.1016/j.colsurfb.2009.08.046, PMID: 19782541.
A del Monte, J. González, L Romero del Sol, C Aragón, F Vega, H Nolasco, J Díaz. (2009) Extraction systems for isolating esterases having interfacial adsorption. Rev. Colomb. Biotecnol. 11, 7-16 (ISSN 0123-3475) .
Ramírez, A.R., Guerra, Y., Otero, A., García, B. Berry, C., Mendiola, J., Hernández-Zanui, A., Chávez, M.A. (2009) Generation of an affinity matrix useful in the purification of natural inhibitors of plasmepsin II, an antimalarial-drug target. Biotechnology and Applied Biochemistry 52: 32-36

2008

Valiente PA, Batista PR, Pupo A, Pons T, Valencia A, Pascutti PG. (2008) Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations. Proteins 73, 440-57 .
Cruz R, Vargas MA, Uribe RM, Pascual I, Lazcano I, Yiotakis A, Matziari M, Joseph-Bravo P, Charli JL (2008) Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release. Peptides 29, 1953-1964 .
Cilli, E.M., Pigossi, F.T., Crusca, E. Jr., Ros, U., Martínez, D., Lanio, M.E., Álvarez, C., Schreier, S. (2007) Correlations between differences in amino terminal sequences and different hemolytic activity of sticholysins. Toxicon 50, 1201-1204 .
Celedón G, González G, Barrientos D, Pino J, Venegas F, Lissi EA, Soto C, Martínez D, Álvarez C, Lanio M. E. (2008) Stycholysin II, a cytolysin from the sea anemone Stichodactyla helianthus promotes higher hemolysis in aged red blood cells. Toxicon 51, 1383-90. .
M.E. Lanio, M.C. Luzardo, C. Álvarez, B. Zadi, Y. Martínez, L. Calderón, M.E. Alonso, D.Q.M. Craig, A. Disalvo, G. Gregoriadis. Humoral immune response against Epidermal Growth Factor encapsulated in Dehydration Rehydration Vesicles of different phospholipid composition. J Liposomes Research. 18: 1 – 19 .

2007

Martínez, D., Otero, A., Álvarez, C., Pazos, F., Tejuca, M., Lanio, M.E., Gutiérrez-Aguirre, I., Barlic, A., Iloro, I., Rodríguez, J.L., González-Mañas, J.M., Lissi, E. (2007). Effect of sphingomyelin and cholesterol in the interaction of St II lipidic interfaces. Toxicon 49, 68-81
Lanio, M. E., Álvarez, C., Ochoa, C., Ros, U., Pazos, F., Martínez, D., Tejuca, M., Eugenio, L.M., Casallanovo, F., Dyszy, F.H., Schreier, S., Lissi, E. (2007). Sticholysins I and II interaction with cationic micelles promotes toxins’ conformational changes and enhanced hemolytic activity. Toxicon 50, 731-739
Pascual, I., Gómez, H., López Chappe, M.A., Saroyán, A., González, Y., Cisneros, M., Charli, J.L. and Chávez, MA. (2007) Screening of inhibitors of dipeptidyl peptidase IV activity in aqueous extracts from marine organisms. Enzyme and Microbial Technology. 40, 414-419.
González, Y., Pons, T., Gil, J., Besada, V., Alonso del Rivero, M., Tanaka, A.S.;, Araujo, M.S. and Chávez, M.A (2007). Characterization and comparative 3D modelling of CmPI-II, a novel “nonclassical” Kazal-type inhibitor from the marine snail Cenchritis muricatus (Mollusca). Biol. Chem. 388, 1183-1194
González, Y., Tanaka, A.S., Hirata, I.Y., del Rivero, M.A., Oliva, M. L. V., Araujo, M. S. and Chávez, M. A. (2007). Purification and preliminary characterization of human neutrophil elastase inhibitors isolated from the marine snail Cenchritis muricatus (Mollusca). Comp. Biochem. Physiol. A Mol Integr Physiol. 146, 506-13 .
Silva-López RE, Morgado-Díaz JA, Chávez MA, Giovanni-De-Simone S. (2007). Effects of serine protease inhibitors on viability and morphology of Leishmania (Leishmania) amazonensis promastigotes. Parasitol Res. 101, 1627-1635.
Otero AJ., S, J., H. Hernandez, M. Sánchez, D. Muirragui, M. Villamar, D. Moreta, M. I. Jiménez, L. Pérez, R. H. Maribona (2007). Monoclonal Antibody-based TAS-ELISA for Quantitative Detection of Mycosphaerella fijiensis Antigens. J Phytopathol 155: 713-719 (e-mail:
Nolasco, H.; del Monte Martínez, A.; Hinojosa, P.; Civera-Cerecedo, R.; Vega-Villasante, F. (2006). Digestibilidad in vitro de lípidos alimentarios para el camarón. Avances en Nutrición Acuícola 7, 377-395 .
Pons T, Montero LA, Febles JP. (2007) Computational biology in Cuba: an opportunity to promote science in a developing country. PLoS Comput Biol. 3, 2047-2051 .
Mansur, M, Martínez, L, Pérez, M, Alonso-del-Rivero, M, Márquez, I, Proenza, Y, Varas, L, and Avilés, FX. (2007) Expression, purification and characterization of porcine pancreatic Carboxypeptidase B from Pichia pastoris for the conversion of recombinant human insulin. Enzyme and Microbial Technology. 40: 476-480

2006

Pazos F, Valle A, Martínez D, Ramírez A, Calderon L, Pupo A, Tejuca M, Morera V, Campos J, Fando R, Dyszy F, Schreier S, Horjales E, Álvarez C, Lanio ME, Lissi E. (2006) Structural and functional characterization of a recombinant sticholysin I (rStI) from the sea anemone Stichodactyla helianthus. Toxicon 48: 1083-1094
Calderon L, Facenda E, Machado L, Uyema K, Rodriguez D, Gomez E, Martínez Y, González B, Bourg V, Álvarez C, Otero A, Russo M, Labrada A, Lanio ME. (2006) Modulation of the specific allergic response by mite allergens encapsulated into liposomes. Vaccine. 24: S38-S39
Charli, JL, Pascual, I, Cruz, R, and Vargas, MA. (2006) Post-secretory inactivation of peptides in the hypothalamic-adenohypophyseal axis: Focus on pyroglutamyl peptidase II, the thyrotropin releasing hormone inactivating ectoenzyme. In: Molecular Endocrinology. P. Joseph-Bravo (Ed.), Research Signpost, Transworld Research Network, Kerala, India. pp: 39-64. ISBN 81-308-0100-0
Mendiola J, Hernández H, Sariego I, Rojas L, Otero A, Ramírez A, Chávez M de L, Payrol JA, Hernández A. (2006) Antimalarial activity from three ascidians: an exploration of different marine invertebrate phyla. Trans R Soc Trop Med Hyg. 100, 909-916
Casallanovo F, de Oliveira FJ, de Souza FC, Ros U, Martínez Y, Penton D, Tejuca M, Martínez D, Pazos F, Pertinhez TA, Spisni A, Cilli EM, Lanio ME, Álvarez C, Schreier S. (2006) Model peptides mimic the structure and function of the N-terminus of the pore-forming toxin sticholysin II. Biopolymers 84, 169-80.
Basulto A, Pérez VM, Noa Y, Varela C, Otero AJ, Pico MC. (2006) Immunohistochemical targeting of sea anemone cytolysins on tentacles, mesenteric filaments, and isolated nematocysts of Stichodactyla helianthus. Journal of Experimental Zoology 305, 253-258
Pons T, González B, Ceciliani F, Galizzi A. (2006). FlgM anti-sigma factors: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. J. Mol. Model. 12: 973-983
Bello, D, Ortega, G, Otero, MA, Saura, G, y Martínez, J. (2006) Poli-hidroxibutiratos. Generalidades, aislamiento y cuantificación. Revista de Plásticos Modernos 91, 81-84 (ISSN 0034-8708)
García-Santana MA, Duconge J, Sarmiento ME, Lanio-Ruíz ME, Becquer MA, Izquierdo L, Acosta-Domínguez A. (2006). Biodistribution of liposome-entrapped human gamma-globulin. Biopharm Drug Dispos 27, 275-83.

2005

G. Celedon, F. Venegas, A.M. Campos, M.E. Lanio, D. Martínez, C. Soto, C. Álvarez, E. Lissi (2005) Role of endogenous channels in red blood cells response to their exposure to the pore forming toxin Sticholysin II. Toxicon 46, 297-307.
Cytotoxic activity of a tumor protease-activated pore forming toxin. Potrich, C., Tomazzolli, R., Dalla Serra, M., Anderluh, G., Malovrh, P., Macek, P., Menestrina, G. & Tejuca, M. (2005). Bioconjugate Chem. 16, 369-376